ANIMAL BARRIER SHARED RESOURCE

动物屏障共享资源(ABSR)通过提供一个 可以进行最高质量动物研究的环境，同时保持 动物护理和动物福利的最高标准。ABSR的一个主要目标是保持 屏障饲养的无特定病原体(SPF)小鼠的健康质量，使它们不受外来小鼠的影响 可能扰乱繁殖或混淆研究结果的感染性因素。提供屏障外壳是为了 SPF小鼠，同时允许调查人员在监督下进入。AECC调查人员保持繁殖 克隆以扩大携带转基因或来自基因操纵的靶向突变的新菌株 或将来自不同基因座的几个特定等位基因重组为一组有限的 单一菌株背景下的基因分型。对于调查人员来说，频繁方便的访问至关重要，以便 它们可能会进行配对，从连续产下的幼崽中收集组织活检，以确定基因类型，以及 观察动物的身体和行为特征(表型)，特别是它们倾向于 发展成肿瘤。此外，许多AECC研究人员使用特定的无病原体啮齿动物，这些啮齿动物 有患自发性肿瘤的遗传倾向或有免疫缺陷和耐受性肿瘤 异种移植作为研究血管生成和转移等特定过程以及测试抗肿瘤作用的模型 治疗。这些研究人员必须经常接触他们的动物才能植入肿瘤 组织，监测肿瘤生长，实施各种治疗，并收集组织活检。畜牧业 服务、兽医护理和全面的啮齿动物质量保证和检疫计划是 由动物研究所(IAS)提供给AECC。IAS由三个教职员工实验室组成 动物兽医(包括主任)、3名兽医技术员、约40名工作人员 动物饲养员，一名设施经理，两名畜牧业主管，以及办公室行政人员。 除了提供兽医护理外，国际兽医协会还监督动物护理和 使用计划，监控法规遵从性，并针对以下方面进行小组和个人培训 调查人员。病理诊断服务由兽医病理学家提供，他还指导 组织病理学共享资源。

The Animal Barrier Shared Resource (ABSR) supports the mission of the AECC by providing an environment in which the highest quality of animal research studies can be conducted while maintaining the highest standards of animal care and animal welfare. A major objective of the ABSR is to maintain the health quality of barrier housed specific pathogen-free (SPF) mice, keeping them free of adventitious murine infectious agents that could disrupt breeding or confound research results. Barrier housing is provided for SPF mice while permitting supervised access for investigators. AECC investigators maintain breeding colonies either to expand novel strains bearing transgene or targeted mutations from genetically-manipulated founder animals, or to recombine several specific alleles from different genetic loci into a limited set of genotypes on a single strain background. Frequent convenient access is crucial for investigators so that they may set up matings, collect tissue biopsies from successive litters for genotype determination, and observe animals for physical and behavioral characteristics (phenotype), specifically, their propensity to develop neoplasia. In addition, many AECC investigators use specific pathogen-free rodents that either have a genetic predisposition to develop spontaneous neoplasia or are immunodeficient and tolerate tumor xenografts as models to study specific processes such as angiogenesis and metastasis and for testing antineoplastic therapies. These investigators must have frequent access to their animals to implant tumor tissues, monitor tumor growth, administer various treatments, and collect tissue biopsies. Animal husbandry services, veterinary care, and comprehensive rodent quality assurance and quarantine programs are provided to the AECC by the Institute of Animal Studies (IAS). The IAS consists of three faculty Laboratory Animal Veterinarians (including the Director), three Veterinary Technicians, a staff of approximately 40 Animal Caretakers, a Facilities Manager, two Husbandry Supervisors, as well as office administrative staff. In addition to providing veterinary care, the IAS veterinarians also provide oversight of the animal care and use program, monitor regulatory compliance, and conduct small-group and individual training sessions for investigators. Pathology diagnostic services are provided by a Veterinary Pathologist who also directs the Histopathology Shared Resource.