BIOINFORMATICS SHARED RESOURCE

生物信息学共享资源(BISR)成立于2004年，致力于开发关系数据库 为AECC研究界提供的数据库资源，作为管理 来自高通量技术(特别是微阵列)的数据，并用于集成来自不同 消息来源。从那时起，BISR建立了基于网络的临床研究数据库，并适应了 管理来自不断发展的微阵列平台和应用的数据；特别是NimbleGen 定制微阵列系统。BISR还被整合到癌症生物医学信息学网格中 (CaBIG)项目，目前与NCI签订了三份合同，以表彰其对该项目的贡献。BISR是 与生物统计共享资源紧密相连，旨在专注于数据管理和 挖掘，将数据分析的责任留给后一种设施。然而，这两家公司的专业知识 Groups已被用于开发AECC的高通量分析能力以及软件 程序来分析在数据库环境中工作的微阵列数据，并且不仅产生 最终输出，但也包括有关数据质量的信息丰富的中间分析。这些分析性的 方法由AECC生物统计学家开发和监督，但由BISR工作人员实施， 利用两个小组的优势来应对不断发展的处理和分析的主要挑战 来自基础和翻译应用的高通量基因组、表观基因组和蛋白质组数据 在这个中心崭露头角并扩张。BISR已经为AECC开发了一个试验性临床研究数据库 头颈部癌症亲和力组织，允许集成来自多个 通过使用可外推的元数据存储库来获取和维护HIPAA合规性 转移到其他疾病地点。正在开发生物信息学基础设施的第二个组成部分，以支持 已有的应用程序，如TransFac、微阵列分析软件、批处理Blat和Entrez分析、 以及生物途径分析工具，如基因MAPP和路径辅助。该设施目前配备了工作人员。 到5.25 FTE，由三名生物信息学家组成，他们为AECC成员提供咨询支持 有两名程序员和一名兼职工作人员担任系统管理员和数据库 管理员。

The Bioinformatics Shared Resource (BISR) was established in 2004 with a focus on developing relational database resources for the AECC research community as the essential foundation for the management of data from high-throughput technologies (especially microarrays), and for the integration of data from different sources. Since then, the BISR has established web-based clinical study databases, and has adapted to the management of data from evolving microarray platforms and applications; in particular, the NimbleGen custom microarray system. The BISR has also been integrated into the cancer biomedical informatics grid (caBIG) project and currently has three contracts from NCI for its contributions to this program. The BISR is closely linked with the Biostatistics Shared Resource and is designed to focus on data management and mining, leaving the responsibility for data analysis with the latter facility. However, the expertise of both groups has been used to develop AECC's high-throughput analytical capabilities along with software programs to analyze microarray data that work within the database environment and generate not only the final output but also intermediate analyses that are informative about data quality. These analytical approaches are developed and supervised by AECC biostatisticians, but implemented by the BISR staff, leveraging the strengths of both groups to meet the evolving major challenge of processing and analyzing high-throughput genomic, epigenomic and proteomic data from basic and translational applications as they emerge and expand at this Center. The BISR has developed a pilot clinical study database for the AECC Head and Neck Cancer Affinity Group that allows the integration of laboratory and clinical data from multiple sources and maintains HIPAA-compliance through the use of metadata repositories that can be extrapolated to other disease sites. A second component to the bioinformatics infrastructure is being developed to support pre-existing applications such as TransFac, microarray analysis software, batched Blat and Entrez analyses, and biological pathway analysis tools such as GenMAPP and PathwayAssist. The facility is currently staffed by 5.25 FTE consisting of three bioinformaticists who provide consultative support to AECC members along with two programmers, and a part-time staff member who serves as a systems administrator and database administrator.