The Einstein-Montefiore Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship program

摘要 这是对R01的一项补充建议，题为了解细胞和转录调控 人类老龄化的变化。它响应NOT-OD-22-057，特别利益通知(NOSI)：行政 《表彰多样性、公平性、包容性和可获得性卓越的补充资料》(DEIA)指导。 亲本R01研究与人类衰老有关的表观遗传事件，超出了典型的 将细胞重新编程事件考虑为系统的细胞亚型比例变化，以及 功能DNA序列变异随年龄变化的揭开。 由于该项目允许开发技术，从而能够深入了解非 具有不同基因血统的人中可以影响疾病风险的编码区具有很强的代表性 通过我们在布朗克斯的社区，该项目吸引了来自不同的、代表性不足的个人 团体，多样性补充剂授予一名土著博士后研究员和一名西班牙裔毕业生 学生。 虽然这种资金就个人而言是非常有价值的，但显然需要有一个更普遍的 制度环境，以促进那些来自通常被排斥群体的人的职业生涯。所描述的鼻音 以上提供了一个机会，以资助一个机构范围的计划，以促进以下这些人的职业生涯- 代表同事。 我们描述了一个密集的一年计划，以开发和实施一个新的课程，以实现这一目标。我们会 利用现有机构资源、开发新计划并利用外部咨询资源 新的、综合的课程。 我们将保护项目参与者和教职员工的时间，并将系统地收集有关 计划，以便我们在年底收集到足够的数据来指导正在进行的资源 投资应该有针对性。 我们的目标是引导我们的机构发展一个公平的环境，提供非常积极的培训 对于那些来自小规模团体的人，培养未来的领导者，他们将放大培训的好处，以 在我们的学术界中占越来越大的一部分。

ABSTRACT This is a proposal for a supplement to the R01 entitled Understanding cellular and transcriptional regulatory changes in human aging. It responds to NOT-OD-22-057, the Notice of Special Interest (NOSI): Administrative Supplements to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship. The parent R01 studies the ‘epigenetic’ events involved with ageing in humans, extending beyond the typical consideration of cellular reprogramming events into systematic cell subtype proportional changes, and the unmasking of functional DNA sequence variants with age. As this project permits the development of techniques that permit insights into DNA sequence variants in non- coding regions that can influence the risk of disease in people of diverse genetic ancestry, represented strongly by our community here in the Bronx, the project has attracted individuals from diverse, under-represented groups, with diversity supplements awarded to an indigenous postdoctoral fellow and a Hispanic graduate student. While such funding is individually very valuable, it has become apparent that there needs to be a more general institutional climate in place to foster the careers of those from typically excluded groups. The NOSI described above provides the opportunity to fund an institution-wide program to enhance the careers of these under- represented colleagues. We describe an intensive one-year plan to develop and implement a new curriculum towards this goal. We will leverage existing institutional resources, develop new programs, and harness external consulting resources in a new, integrated course. We will protect the time of program participants and faculty, and will collect information systematically about the program so that we will, at the end of the year, have collected enough data to direct how ongoing resource investment should be targeted. Our goal is to guide our institution’s development of an equitable environment that provides very active training for those from minoritized groups, developing the future leaders who will amplify the benefits of the training to an increasingly large part of our academic community.