DNA Damage and Cellular Defense

DNA损伤和细胞防御(DDCD)计划是一个由23名成员组成的高度互动的小组 维克森林大学综合癌症中心，代表7个系和科室。这个 DDCD方案的总体科学目标是了解 细胞持续-或者通过预防或修复-对DNA或其他关键的 大分子结构。该计划鼓励采用任何一种小说的翻译策略 化学治疗药物或化学预防药物。可以代表DDCD计划中的研究重点 在两个主题目标内：1)确定DNA和其他大分子的损伤机制 化学制剂或辐射，以及这种损害如何导致有害的致癌作用或有益的影响 抗癌作用(化疗和放射治疗)；以及2)确定细胞防御机制， 在预防肿瘤发生和调节肿瘤对细胞毒化疗敏感性中的作用 放射疗法。DDCD计划拥有强大的资金和生产力记录。NCI和其他合计 自上次审查以来，经同行审查的资金从181万美元增至628万美元，增加了两倍多。成员是 互动性强，203份方案内出版物中有54份(26.6%)，18份方案间出版物 出版物(8.9%)。此外，一些赠款共同调查产生于已建立的和 新的合作(66.7%的赠款与CCCWFU的另一成员有正式合作)。成员 依靠CCCWFU的核心实验室服务来支持他们的研究，并高效地利用CCCWFU 试点资金：许多试点项目已成熟为赠款申请，有些项目已成为资助赠款。这个 该计划以两周一次的研讨会形式举行会议，并举行年度务虚会。三个新的月息 小组已经开始，一个小组关于抗氧化酶的信号功能，第二个小组关于DNA损伤， 修复和突变，以及第三组临床医生和基础科学家开发新的翻译 在肺癌方面的研究合作。

The DNA Damage and Cellular Defense (DDCD) Program is a highly interactive group of 23 members of the Comprehensive Cancer Center of Wake Forest University, representing 7 Departments and Sections. The overall scientific goal within the DDCD Program is to understand the mechanisms and processes whereby cells sustain - or alternatively, mitigate by prevention or repair - damage to DNA or other critical macromolecular structures. The Program encourages translational strategies that employ either novel chemotherapeutics or chemopreventive agents. Research focus in the DDCD program can be represented within two thematic aims: 1) To determine mechanisms of damage to DNA and other macromolecules by chemical agents or radiation, and how this damage results in detrimental carcinogenic effects or beneficial anticancer effects (in chemc¿ and radiation therapy); and 2) To identify cellular defense mechanisms that function in prevention of carcinogenesis and modulation of tumor sensitivity to cytotoxic chemotherapy and radiation therapy. The DDCD Program has a strong funding and productivity record. Total NCI and other peer-reviewed funding has more than tripled from $1.81M to $6.28M since the previous review. Members are highly interactive, with 54 of 203 intra-programmatic publications (26.6%) and 18 inter-programmatic publications (8.9%). Also, a number of grant co-investigatorships have resulted from both established and new collaborations (66.7% of grants have a formal collaboration with another CCCWFU member). Members rely on CCCWFU core lab services in support of their research, and have made efficient use of CCCWFU pilot funding: many pilot projects have matured into grant applications and some into funded grants. The Program meets in a biweekly seminar format, and holds an annual retreat. Three new monthly interest subgroups have begun, one on signaling functions of antioxidant enzymes, a second on DNA damage, repair, and mutagenesis, and a third group of clinicians and basic scientists to develop new translational research collaborations in lung cancer.