Multidisciplinary Training in Molecular Toxicology

描述(由申请人提供) 一个多学科的博士后和博士后培训计划 提出了分子毒理学，重点研究了环境毒物。博士前 培训候选人将在现有的四个基本培训范围内接受培训 理科课程(生物化学、分子遗传学、生理学和 药理学和癌症生物学)在一个独特的课程中修改了课程和 其他要求。从某种意义上说，这项计划即将启动 16位导师中的大多数都有博士后培训经验 候选人和/或博士后研究员独立发挥作用 机械毒物学的研究人员。事实上，许多人目前都是顾问 对于一个或多个个人。这笔培训补助金的目的是提供 支持协调一致、具有凝聚力的培训计划 受监督并高度互动。该计划将提供最先进的 分子毒理学培训，主要集中在两个领域： 1)在细胞水平上理解毒性损伤的分子机制 (特别强调DNA损伤)；以及2)定义功能， 细胞防御途径的调控及其与疾病的相关性 有毒的侮辱。一个密切相关的辅助目标将是培训研究人员 在对个体间的机械性后果的研究中 对中毒损伤的遗传易感性的差异。包括教职员工在内 因为这个培训项目的导师都是有经验的独立人士 毒理损伤机制、细胞途径的研究进展 防御和/或可能改变个体易感性的基因多态 由化学物质引起的疾病。该计划旨在提供以下培训 将使未来的研究人员具备广泛的基础科学基础 知识，对相关科学文献的扎实掌握，以及 适用于多种分子生物学研究技能的调色板 毒物学问题。这项计划将满足对调查人员的需求 接受过分子机制层面的毒理学培训，重点是 特定基因或一组基因所扮演的角色。调查人员将 鼓励研究基因与环境的相互作用，特别强调 论与基因相关的基因多态的功能意义 环境毒理学。

DESCRIPTION (Provided by Applicant) A multi-disciplinary program for pre-doctoral and postdoctoral training in molecular toxicology is proposed, with emphasis on environmental agents. Pre-doctoral training candidates will be trained within four existing basic science curricula (Biochemistry, Molecular Genetics, Physiology and Pharmacology, and Cancer Biology) in a unique program with modified course and other requirements. This program is poised for initiation in the sense that most of the sixteen mentors are experienced in the training of pre-doctoral candidates and/or postdoctoral fellows to function independently as investigators in mechanistic toxicology. Indeed, many are currently advisors for one or more individuals. The purpose of this training grant is to provide support for a coordinated and cohesive training program that will be supervised and highly interactive. The program will provide state-of-the art training in molecular toxicologic sciences, with primary focus in two areas: 1) understanding molecular mechanisms of toxic injury at the cellular level (with special emphasis on DNA damage); and 2) defining the functionality, regulation, and disease relevance of pathways of cellular defense against toxic insult. A closely related ancillary goal will be to train researchers in the investigation of the mechanistic consequences of interindividual differences in genetic predisposition to toxic injury. The faculty included as mentors in this training program are all experienced independent investigators of mechanisms of toxicologic damage, pathways of cellular defense, and/or genetic polymorphisms that may alter individual susceptibility to chemical-induced disease. The program is designed to provide training that will prepare future investigators with a broad foundation of basic science knowledge, a solid grasp of the relevant scientific literature, and a versatile palette of molecular biologic research skills for application to toxicologic questions. This program will fill a need for investigators trained in toxicologic science at the molecular mechanistic level, focusing on the roles played by specific genes or sets of genes. The investigators will encourage research on gene-environment interactions, with particular emphasis on the functional significance of genetic polymorphisms that are relevant to environmental toxicology.