Multidisciplinary Training in Molecular Toxicology

描述（申请人提供） 一个多学科的计划，为博士前和博士后培训， 提出了分子毒理学，重点是环境因素。博士前 培训候选人将在现有的四个基本 科学课程（生物化学，分子遗传学，生理学和 药理学和癌症生物学）在一个独特的程序与修改的课程， 其他要求。这个项目准备启动， 16位导师中的大多数都有博士前培训的经验 候选人和/或博士后研究员独立运作， 机械毒理学的研究者事实上，许多人目前是顾问 一个或多个人。该培训补助金的目的是提供 支持协调一致的培训计划， 监督和高度互动。该计划将提供最先进的 分子毒理学科学培训，主要侧重于两个领域： 1)在细胞水平上理解毒性损伤的分子机制 (with特别强调DNA损伤）;和2）定义功能性， 调节和疾病相关性的细胞防御途径， 有毒的侮辱一个密切相关的辅助目标将是培训研究人员 在调查个体间的机械后果时， 对毒性损伤的遗传易感性的差异。教师包括 作为这个培训项目的导师， 毒理学损伤机制的研究者，细胞 防御，和/或遗传多态性，可能会改变个人的易感性 化学物质引起的疾病该计划旨在提供培训， 将为未来的研究人员提供广泛的基础科学基础 知识，扎实掌握相关科学文献， 分子生物学研究技能的多功能调色板， 毒理学问题这个项目将满足调查人员的需求 在分子机制水平上接受毒理学科学培训，重点是 特定基因或基因组所起的作用。调查人员将 鼓励研究基因与环境的相互作用， 基因多态性的功能意义， 环境毒理学

DESCRIPTION (Provided by Applicant) A multi-disciplinary program for pre-doctoral and postdoctoral training in molecular toxicology is proposed, with emphasis on environmental agents. Pre-doctoral training candidates will be trained within four existing basic science curricula (Biochemistry, Molecular Genetics, Physiology and Pharmacology, and Cancer Biology) in a unique program with modified course and other requirements. This program is poised for initiation in the sense that most of the sixteen mentors are experienced in the training of pre-doctoral candidates and/or postdoctoral fellows to function independently as investigators in mechanistic toxicology. Indeed, many are currently advisors for one or more individuals. The purpose of this training grant is to provide support for a coordinated and cohesive training program that will be supervised and highly interactive. The program will provide state-of-the art training in molecular toxicologic sciences, with primary focus in two areas: 1) understanding molecular mechanisms of toxic injury at the cellular level (with special emphasis on DNA damage); and 2) defining the functionality, regulation, and disease relevance of pathways of cellular defense against toxic insult. A closely related ancillary goal will be to train researchers in the investigation of the mechanistic consequences of interindividual differences in genetic predisposition to toxic injury. The faculty included as mentors in this training program are all experienced independent investigators of mechanisms of toxicologic damage, pathways of cellular defense, and/or genetic polymorphisms that may alter individual susceptibility to chemical-induced disease. The program is designed to provide training that will prepare future investigators with a broad foundation of basic science knowledge, a solid grasp of the relevant scientific literature, and a versatile palette of molecular biologic research skills for application to toxicologic questions. This program will fill a need for investigators trained in toxicologic science at the molecular mechanistic level, focusing on the roles played by specific genes or sets of genes. The investigators will encourage research on gene-environment interactions, with particular emphasis on the functional significance of genetic polymorphisms that are relevant to environmental toxicology.