Multidisciplinary Training in Molecular Toxicology

分子毒理学多学科培训

• 批准号: 6604030
• 负责人: ALAN J TOWNSEND
• 金额: $ 30.36万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6604030
• 关键词: Multidisciplinary; Training; Molecular; Toxicology

DESCRIPTION (Provided by Applicant) A multi-disciplinary program for pre-doctoral and postdoctoral training in molecular toxicology is proposed, with emphasis on environmental agents. Pre-doctoral training candidates will be trained within four existing basic science curricula (Biochemistry, Molecular Genetics, Physiology and Pharmacology, and Cancer Biology) in a unique program with modified course and other requirements. This program is poised for initiation in the sense that most of the sixteen mentors are experienced in the training of pre-doctoral candidates and/or postdoctoral fellows to function independently as investigators in mechanistic toxicology. Indeed, many are currently advisors for one or more individuals. The purpose of this training grant is to provide support for a coordinated and cohesive training program that will be supervised and highly interactive. The program will provide state-of-the art training in molecular toxicologic sciences, with primary focus in two areas: 1) understanding molecular mechanisms of toxic injury at the cellular level (with special emphasis on DNA damage); and 2) defining the functionality, regulation, and disease relevance of pathways of cellular defense against toxic insult. A closely related ancillary goal will be to train researchers in the investigation of the mechanistic consequences of interindividual differences in genetic predisposition to toxic injury. The faculty included as mentors in this training program are all experienced independent investigators of mechanisms of toxicologic damage, pathways of cellular defense, and/or genetic polymorphisms that may alter individual susceptibility to chemical-induced disease. The program is designed to provide training that will prepare future investigators with a broad foundation of basic science knowledge, a solid grasp of the relevant scientific literature, and a versatile palette of molecular biologic research skills for application to toxicologic questions. This program will fill a need for investigators trained in toxicologic science at the molecular mechanistic level, focusing on the roles played by specific genes or sets of genes. The investigators will encourage research on gene-environment interactions, with particular emphasis on the functional significance of genetic polymorphisms that are relevant to environmental toxicology.

描述（由申请人提供） 博士前和博士后培训的多学科计划 提出了分子毒理学，重点是环境因素。博士预科 培训候选人将在现有的四个基本基础范围内接受培训 科学课程（生物化学、分子遗传学、生理学和 药理学和癌症生物学）在一个独特的课程中，经过修改的课程和 其他要求。该计划已准备好启动，因为 十六位导师中大部分具有博士前培养经验 候选人和/或博士后研究员独立运作 机械毒理学研究人员。事实上，许多人目前担任顾问 对于一个或多个人。该培训补助金的目的是提供 支持协调一致的培训计划 监督和高度互动。该计划将提供最先进的 分子毒理学科学培训，主要关注两个领域： 1）了解细胞水平毒性损伤的分子机制 （特别强调DNA损伤）； 2）定义功能， 细胞防御途径的调节和疾病相关性 有毒的侮辱。一个密切相关的辅助目标是培训研究人员 在研究个体间的机械后果时 中毒性损伤的遗传易感性差异。师资队伍包括 由于本次培训项目的导师都是经验丰富的独立导师 毒理学损伤机制、细胞途径的研究人员 防御和/或可能改变个体易感性的遗传多态性 化学引起的疾病。该计划旨在提供以下培训： 将为未来的研究人员提供广泛的基础科学基础 知识、对相关科学文献的扎实掌握以及 分子生物学研究技能的多功能调色板，可应用于 毒理学问题。该计划将满足调查人员的需求 在分子机制水平上接受过毒理学科学培训，重点是 特定基因或基因组所发挥的作用。调查人员将 鼓励基因与环境相互作用的研究，特别强调 与相关的遗传多态性的功能意义 环境毒理学。