Core--Clinical Facility

宾夕法尼亚大学卫生系统(UPHS)为宾夕法尼亚大学医院、长老会医疗中心、费城退伍军人管理医疗中心、宾夕法尼亚医院和费城儿童医院的2500多名艾滋病毒感染者提供护理。宾夕法尼亚大学艾滋病研究中心的临床核心将维护和扩大一个纵向数据库，该数据库目前包括1,600多名感染艾滋病毒的男性、女性、青少年和在UPHS接受护理的儿童的人口统计、行为和临床信息。临床核心数据库可以用来确定潜在的研究对象，或者，当与其他三个具有深入临床信息的校园数据库链接时，可以用作独立临床研究的工具。我们将扩大这个数据库，将3000名艾滋病毒感染者的信息包括在内。此外，临床核心还创建了一个与数据库链接的标本存储库，其中包含每半年收集一次的数千个储存的血浆、血清和外周血单核细胞(PBMC)。今后我们将继续定期采集血清和血浆样本。应研究人员的要求，将收集新鲜的PBMC，并从每个参与者那里获取PBMC样本，用于制备适合宿主遗传分析的DNA。这些资源将用于促进宾夕法尼亚大学校区的跨学科和翻译研究。数据库将扩大到包括三个领域的新数据元素，即抗逆转录病毒治疗的代谢并发症、肝炎合并感染以及坚持和危险行为，以支持正在进行的 并计划对年轻的和新的艾滋病毒调查人员进行研究。临床核心将协调 收集更广泛的患者材料，包括通过分离收集的细胞、生殖器分泌物和脂肪组织。宾夕法尼亚大学和对艾滋病毒发病机制、抗逆转录病毒治疗及其并发症、机会性感染、神经和精神并发症、依从性、艾滋病毒危险行为和传播以及生活质量感兴趣的地区调查人员将聚集在一起，扩大当前研究的重点，并在感兴趣的领域建立合作。

The University of Pennsylvania Health System (UPHS) provides care to over 2,500 HIV-infected individuals at the Hospital of the University of Pennsylvania, Presbyterian Medical Center, the Philadelphia Veterans Administration Medical Center, Pennsylvania Hospital, and Children's Hospital of Philadelphia. The Clinical Core of the Penn Center for AIDS Research will maintain and expand a longitudinal database that currently includes demographic, behavioral, and clinical information on over 1,600 HIV-infected men, women, adolescents, and children receiving care in the UPHS. The Clinical Core Database can be used to identify potential subjects for study or, when linked with three other campus databases with in-depth clinical information, can be used as a tool for independent clinical investigation. We will expand this Database to include information on 3,000 HIV-infected individuals. In addition, the Clinical Core has created a Specimen Repository, linked to the Database, which contains several thousand banked plasma, serum, and peripheral blood mononuclear cells (PBMCs) collected semiannually. We will continue to collect serum and plasma samples at regular intervals in the future. Fresh PBMCs will be collected by investigator request, and a PBMC sample from each participant will be obtained for preparation of DNA suitable for host genetic analyses. These resources will be used to promote interdisciplinary and translational research on the Penn campus. The Database will be expanded to include new data elements in three areas, metabolic complications of antiretroviral therapy, hepatitis co-infection, and adherence and at-risk behaviors in order to support on-going and planned research of young and new HIV investigators. The Clinical Core will coordinate the collection of a wider range of patient material, including cells collected by apheresis, genital secretions, and adipose tissue. Penn and regional investigators with interests in HIV pathogenesis, antiretroviral therapy and its complications, opportunistic infections, neurological and psychiatric complications, adherence, HIV risk behaviors and transmission, and quality of life will be brought together to expand the focus of current research and establish collaborations across fields of interest.