Core--Clinical Facility

宾夕法尼亚大学卫生系统（UPHS）为宾夕法尼亚大学医院、长老会医疗中心、费城退伍军人管理局医疗中心、宾夕法尼亚医院和费城儿童医院的2,500多名艾滋病毒感染者提供护理。宾夕法尼亚大学艾滋病研究中心的临床核心将维护和扩大一个纵向数据库，该数据库目前包括在UPHS接受护理的1，600多名艾滋病毒感染男性，女性，青少年和儿童的人口统计，行为和临床信息。临床核心数据库可用于确定潜在的研究对象，或者与其他三个具有深入临床信息的校园数据库链接时，可用作独立临床研究的工具。我们将扩大这一数据库，以包括3 000名艾滋病毒感染者的信息。此外，临床中心还创建了一个与数据库相连的标本库，其中包含数千份库存血浆、血清和外周血单核细胞（PBMC），每半年采集一次。我们将继续定期收集血清和血浆样本。将根据研究者要求采集新鲜PBMC，并从每例受试者中采集PBMC样本，用于制备适用于宿主遗传分析的DNA。这些资源将用于促进宾夕法尼亚大学校园的跨学科和翻译研究。该数据库将扩大到包括三个领域的新数据元素，即抗逆转录病毒治疗的代谢并发症、肝炎合并感染以及依从性和高危行为，以支持正在进行的 和计划中的年轻和新的艾滋病毒研究人员的研究。临床中心将协调 收集更广泛的患者材料，包括通过单采术收集的细胞、生殖器分泌物和脂肪组织。宾夕法尼亚大学和区域研究人员对艾滋病毒发病机制，抗逆转录病毒治疗及其并发症，机会性感染，神经和精神并发症，依从性，艾滋病毒风险行为和传播以及生活质量感兴趣，将汇集在一起，以扩大当前研究的重点，并建立跨感兴趣领域的合作。

The University of Pennsylvania Health System (UPHS) provides care to over 2,500 HIV-infected individuals at the Hospital of the University of Pennsylvania, Presbyterian Medical Center, the Philadelphia Veterans Administration Medical Center, Pennsylvania Hospital, and Children's Hospital of Philadelphia. The Clinical Core of the Penn Center for AIDS Research will maintain and expand a longitudinal database that currently includes demographic, behavioral, and clinical information on over 1,600 HIV-infected men, women, adolescents, and children receiving care in the UPHS. The Clinical Core Database can be used to identify potential subjects for study or, when linked with three other campus databases with in-depth clinical information, can be used as a tool for independent clinical investigation. We will expand this Database to include information on 3,000 HIV-infected individuals. In addition, the Clinical Core has created a Specimen Repository, linked to the Database, which contains several thousand banked plasma, serum, and peripheral blood mononuclear cells (PBMCs) collected semiannually. We will continue to collect serum and plasma samples at regular intervals in the future. Fresh PBMCs will be collected by investigator request, and a PBMC sample from each participant will be obtained for preparation of DNA suitable for host genetic analyses. These resources will be used to promote interdisciplinary and translational research on the Penn campus. The Database will be expanded to include new data elements in three areas, metabolic complications of antiretroviral therapy, hepatitis co-infection, and adherence and at-risk behaviors in order to support on-going and planned research of young and new HIV investigators. The Clinical Core will coordinate the collection of a wider range of patient material, including cells collected by apheresis, genital secretions, and adipose tissue. Penn and regional investigators with interests in HIV pathogenesis, antiretroviral therapy and its complications, opportunistic infections, neurological and psychiatric complications, adherence, HIV risk behaviors and transmission, and quality of life will be brought together to expand the focus of current research and establish collaborations across fields of interest.