Center for Aids Research (CFAR)

描述（由申请人提供）：杜克艾滋病研究中心（CFAR）的主要使命是建立和支持一个学术环境，促进和鼓励所有艾滋病相关的研究活动在杜克校内合作和协调，从而服务于所有艾滋病调查人员及其研究计划的要求。这个新的CFAR应用程序是围绕建立一系列关键的核心设施，旨在服务于基础和临床艾滋病研究界的科学需求，从而促进艾滋病毒感染的预防和治疗的快速进展。发展核心将支持一项为创新试点研究项目提供资金的年度计划，以及一项为快速突破的艾滋病毒相关研究提供资金的单独计划。此外，发展核心将与杜克大学医学院以及几个临床和基础科学部门合作启动一项教师招聘计划。流式细胞术核心将提供艾滋病毒感染和未感染样本的最先进的表型和功能分析，以及校园内唯一的BSL-3设施，能够从艾滋病毒感染样本中高速分选细胞亚群。分子病毒学核心将提供病毒学试剂（即，质粒、载体和RNAi）以及关键的病毒学服务，如病毒定量、分离、克隆、测序和繁殖，以满足杜克艾滋病研究界的需求。生物信息学和生物统计学核心将为所有基础和临床研究者提供专门的建模和统计支持。最后，临床核心将提供国内以及国际患者相关的材料和培训，以加强对有见地的艾滋病临床研究的关注，特别强调对全球健康至关重要的问题。将通过常设外部咨询委员会的活动、全面成果评估计划和有效的战略规划进程来确保《非洲财务报告准则》的使命。

DESCRIPTION (provided by applicant): The principal mission of the Duke Center for AIDS Research (CFAR) is to establish and support an academic environment that promotes and encourages the intramural collaboration and coordination of all AIDS-related research activities at Duke, thus serving the requirements of all AIDS investigators and their research programs. This new CFAR application is structured around the establishment of a series of critical Core facilities designed to serve the scientific needs of the basic and clinical AIDS research community and thus facilitate rapid progress in the prevention and treatment of HIV infection. The Delopmental Core will support an annual program for funding innovative pilot research projects as well as a separate funding program for fast-breaking HIV-related research. Additionally, the Developmental Core will initiate a faculty recruitment program in partnership with the Duke University School of Medicine as well as several clinical and basic science Departments. The Flow Cytometry Core will provide state-of-the-art phenotypic and functional analyses of HIV-infected and uninfected samples as well as the only BSL-3 facility on campus capable of high speed sorting of cellular subpopulations from HIV-infected samples. The Molecular Virology Core will provide virologic reagents (i.e., plasmids, vectors, and RNAi) as well as critical virologic services such as viral quantitation, isolation, cloning, sequencing and propagation to meet the needs of the Duke AIDS research community. The Bioinformatics and Biostatistical Core will provide dedicated modeling and statistical support for all basic and clinical investigators. Finally, the Clinical Core will provide access to domestic as well as international patient-related materials and training in order to enhance the focus on insightful clinical AIDS research with specific emphasis on issues critical to Global Health. The CFAR mission will be ensured through the activities of a permanent External Advisory Board, a comprehensive outcomes assessment plan and an effective strategic planning process.