Genetic Variants in Immunological Mediator Genes and Skin Cancer Risk

描述(申请人提供)：免疫调节基因的遗传变异与皮肤癌风险大量的生物证据表明，免疫监测在预防皮肤癌方面发挥着关键作用。然而，常见的遗传变异在免疫监视基因中的重要性以及它们与构成宿主因素和紫外线暴露史在导致皮肤癌方面的相互作用在很大程度上是未知的；存在稀少的数据。我们建议在护士健康研究(219例黑色素瘤、286例鳞状细胞癌、300例基底细胞癌和874例匹配对照)内的嵌套病例对照研究中，同时详细检查9种免疫介质基因的遗传变异与黑色素瘤、鳞状细胞癌和基底细胞癌的风险。这项创新性的工作将推动这一领域的发展，通过使用互补的方法来评估常见的变异，即评估假定的功能SNPs和选择Tag-SNPs来测试未知的常见功能变异与皮肤癌风险的关联，以及探索性的路径分析。此外，我们还将评估这些基因中的遗传变异与构成宿主因素和紫外线暴露史之间的相互作用对皮肤癌风险的影响。这项建议将利用现有特征良好的队列中嵌套的研究机会，包括队列特征、设计质量、高跟踪率、大样本量、预期宿主风险因素评估的严谨性以及回溯性问卷的高回复率。我们的研究还将利用之前确诊的三种皮肤癌病例、储存的血液和DNA样本，以及之前收集的关于宿主风险因素和紫外线暴露史的信息。这项研究将有助于为识别皮肤癌高危人群和提供个性化的风险管理策略提供科学基础。我们建议详细评估免疫介质基因的遗传变异与黑色素瘤、鳞状细胞癌和基底细胞癌同时发生的风险。这项创新的工作将通过使用互补的方法系统地评估共同的变种来推动这一领域的发展。这项研究将有助于确定皮肤癌高危人群的科学基础，并提供个性化的风险管理策略。

DESCRIPTION (provided by applicant): Genetic variants in immunological mediator genes and skin cancer risk Substantial biologic evidence indicates that the immune surveillance plays a critical role in protecting against skin cancer. However, the importance of common inherited variants in the immune surveillance genes and their interactions with constitutional host factors and UV exposure history in causing skin cancer is largely unknown; sparse data exist. We propose to examine in detail the genetic variants in 9 immunological mediator genes with the risk of melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) simultaneously in a nested case-control study within the Nurses Health Study (219 melanoma cases, 286 SCC cases, 300 BCC cases, and 874 matched controls). This innovative work will move this field forward, by evaluating common variants using complementary approaches, i.e. to evaluate putative functional SNPs and to choose tag- SNPs to test for associations of unknown common functional variants with skin cancer risk, along with exploratory pathway analyses. In addition, we will also assess the interactions between genetic variants in these genes and constitutional host factors and UV exposure history on skin cancer risk. This proposal will take advantage of the research opportunities nested within the existing well-characterized cohort, including cohort characteristics, quality of design, high follow-up rate, large sample size, rigor in prospective host risk factor assessment, and high response rate of retrospective questionnaires. Our study will also take advantage of the previously confirmed cases of the three types of skin cancers, stored blood and DNA samples, as well as previously collected information on host risk factors and UV exposure history. This research will contribute to the scientific basis for identifying high-risk individuals for skin cancer and providing individualized risk management strategies. We propose a detailed evaluation of genetic variation in immunological mediator genes in relation to the risks of melanoma, squamous cell carcinoma, and basal cell carcinoma simultaneously. This innovative work will move this field forward, by systematically evaluating common variants using complementary approaches. This research will contribute to the scientific basis for identifying individuals at high-risk for skin cancer and providing individualized risk management strategies.