T CELL MEMORY
T CELL MEMORY
批准号:
7562626
负责人:
JOSHY JACOB
金额:
$6.55万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-05-01 至 2008-04-30
关键词:
Acquired Immunodeficiency SyndromeCancerousCellsComputer Retrieval of Information on Scientific Projects DatabaseDevelopmentFundingGrantInstitutionKnowledgeMemoryMemory B-LymphocyteModelingResearchResearch PersonnelResourcesSourceTime StudyUnited States National Institutes of HealthVaccinesdesigninsight
中文摘要
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
关于艾滋病
我们现在可以,第一次,直接研究记忆B细胞,我们正在使用这个模型来回答关于B细胞记忆的基本问题。随着项目的进展,我们对记忆B淋巴细胞的发育、持久性和功能有了更好的了解。这些知识将为设计策略提供重要见解,以开发有效的疫苗,保护宿主免受癌细胞的侵害。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Regarding AIDS
We can now, for the first time, study memory B cell directly and we are using this model to answer fundamental questions about B cell memory. As the project progresses, we are gaining a better understanding of the development, persistence, and function of memory B lymphocytes. This knowledge will provide critical insights into designing strategies to develop efficient vaccines that can protect the host against cancerous cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Somatic hypermutation and rescue from self-reactivity in Pre-B lymphocytes
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批准号:10153689
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项目类别:
-
资助金额:$21.17万
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财政年份:2020
-
负责人:JOSHY JACOB
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依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8534701
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项目类别:
-
资助金额:$48.19万
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财政年份:2012
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负责人:JOSHY JACOB
-
依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8704872
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项目类别:
-
资助金额:$47.85万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8899425
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项目类别:
-
资助金额:$65.98万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
Negative regulation of Plasma cells by CD28 and B7 molecules
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批准号:8513589
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项目类别:
-
资助金额:$44.57万
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财政年份:2012
-
负责人:JOSHY JACOB
-
依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:9114473
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项目类别:
-
资助金额:$47.06万
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财政年份:2012
-
负责人:JOSHY JACOB
-
依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8299339
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项目类别:
-
资助金额:$50.37万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
B CELL MEMORY AND ORIGINAL ANTIGENIC SIN
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批准号:8357483
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项目类别:
-
资助金额:$4.12万
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财政年份:2011
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负责人:JOSHY JACOB
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依托单位:
B CELL MEMORY
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批准号:8172441
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项目类别:
-
资助金额:$5.48万
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财政年份:2010
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负责人:JOSHY JACOB
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依托单位:
B CELL MEMORY
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批准号:7958268
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项目类别:
-
资助金额:$5.67万
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财政年份:2009
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7958181
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项目类别:
-
资助金额:$5.67万
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财政年份:2009
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负责人:JOSHY JACOB
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依托单位:
NOVEL VLP VACCINES FOR PANDEMIC INFLUENZA VIRUS
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批准号:7715818
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项目类别:
-
资助金额:$2.85万
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财政年份:2008
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7715766
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项目类别:
-
资助金额:$3.56万
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财政年份:2008
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负责人:JOSHY JACOB
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依托单位:
NOVEL VLP VACCINES FOR PANDEMIC INFLUENZA VIRUS
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批准号:7562687
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项目类别:
-
资助金额:$3.16万
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财政年份:2007
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负责人:JOSHY JACOB
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依托单位:
B LYMPHOCYTES, IMMUNOLOGIC MEMORY, CELLULAR IMMUNITY, TRANSGENIC ANIMAL
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批准号:7349295
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项目类别:
-
资助金额:$4.01万
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财政年份:2006
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7349159
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项目类别:
-
资助金额:$4.01万
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财政年份:2006
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7165888
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项目类别:
-
资助金额:$3.08万
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财政年份:2005
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负责人:JOSHY JACOB
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依托单位:
Enhancing HIV vaccine efficacy by blocking regulatory T cells
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批准号:7006383
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项目类别:
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资助金额:$25.35万
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财政年份:2005
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负责人:JOSHY JACOB
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依托单位:
Enhancing HIV vaccine efficacy by blocking regulatory T cells
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批准号:7140591
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项目类别:
-
资助金额:$24.75万
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财政年份:2005
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:6970959
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项目类别:
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资助金额:$3.44万
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财政年份:2004
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负责人:JOSHY JACOB
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依托单位:
海外基金