GNRH WEBSITE (U-54 SUPPLEMENT)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 GnRH网站项目正在实现其目标，即向GnRH途径的系统生物学模型以及相关的临床和研究资源提供基于网络的界面。我们组建了一个由Christopher Dubay博士领导的生物信息学家团队(来自俄亥俄州立大学医学信息学和临床流行病学生物医学信息学项目的两名硕士和一名博士生)，他们都在该项目的各个方面工作。我们已经部署了网站的内部版本，并正在与ONPRC的研究人员一起迭代地设计功能，最活跃的是Sergio Ojeda博士。该网站目前包含GnRH受体系统的交互信号通路，具有支持所描述的相互作用的文献注释的元件间链接。该模型将扩展到包括下丘脑GnRH分泌的控制和其他调节GnRH神经元活动的机制。通过允许用户制作带有用户添加注释的模型版本，它也将变得更具互动性。这些版本，包括不同物种的版本，将具有可比性，有助于在视觉上突出不同版本之间的差异(使用Adobe SVG：http://www.adobe.com/svg/).等信息学技术

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The GnRH Website project is making good progress in accomplishing its goal of delivering a web based interface to systems biology models of the GnRH pathway and related clinical and research resources. We have assembled a team of bioinformaticians (two Masters, and one PhD student from the OHSU Department of Medical Informatics & Clinical Epidemiology Biomedical Informatics program) being led by Dr. Christopher Dubay, who are all working on various aspects of the project. We have deployed an internal version of the web site, and are iteratively designing the functionality with ONPRC researchers; most actively Dr. Sergio Ojeda. The site currently contains an interactive signaling pathway for the GnRH receptor system with inter-element links annotated by literature references supporting the depicted interactions. The model will be extended to include the control of hypothalamic GnRH secretion and other mechanisms regulating GnRH neuronal activity. It will be also made more interactive by allowing users to make versions of models with user added annotations. These versions, including versions for various species, will be comparable in a way that helps visually highlight differences between versions (using informatics technologies such as Adobe SVG: http://www.adobe.com/svg/).