OVARIAN REGULATION OF BONE DENSITY AND FAT MASS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目的总体目标是确定卵巢对循环中三角洲样同系物(DLK1)水平的贡献，DLK1是一种调节脂肪细胞和成骨细胞发育的多肽因子。虽然几项研究表明卵巢类固醇，特别是雌二醇，在调节女性肥胖和骨密度方面有一定作用，但卵巢来源的蛋白质激素参与这些过程的情况却知之甚少。根据初步数据显示，灵长类卵巢是有限数量的表达DLK1的组织之一，研究旨在确定在雌性猕猴血液循环中发现的显著水平的DLK1是否来自卵巢，或受卵巢调控。猕猴将被用于这个项目，因为它们是女性的优秀实验替代品，因为它们的荷尔蒙特征和卵巢周期长度相似。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to determine ovarian contribution to the circulating levels of delta-like 1 homolog (DLK1), a peptide factor that regulates adipocyte and osteoblast development. While several studies have implicated ovarian steroids, particularly estradiol, in the regulation of female adiposity and bone density, protein hormones of ovarian origin involved in these processes are poorly understood. Based on preliminary data demonstrating that the primate ovary is one of a limited number of tissues expressing DLK1, studies were designed to determine if the significant levels of DLK1 found in the circulation of female macaques originates from, or are regulated by, the ovary. Rhesus macaques will be used in this project as they serve as excellent experimental surrogates for women because of their similar hormonal profiles and ovarian cycle lengths.