Biostatistics/Bioinformatics Core

前列腺癌孢子生物统计学和生物信息学核心的目标是：(A)维护和 继续开发孢子的临床和组织数据库，(B)提供实验设计， 向所有孢子项目提供流行病学和生物统计方面的专门知识(C)进行数据分析和(D) 为孢子间和其他科学合作提供基础设施和专业知识。的专业知识 这个核心的关键成员促进了孢子临床试验、生物标记物的规划、开发和分析 研究、分子诊断和高通量技术，如DNA/RNA微阵列、组织 基因芯片、蛋白质组学实验和回顾性研究。孢子生物统计学与生物信息学 CORE利用生物统计共享资源和生物信息学的现有资源和专业知识 西北大学罗伯特·H·鲁里综合癌症中心资源共享。这 使核心能够以最低的成本提供全面的生物信息学和生物统计服务。在.期间 在过去的供资期间，核心开发了一个完全可运作的、基于网络的、以CDE为驱动的(共同数据 元素)保存前列腺癌临床、组织和实验室数据的孢子的中央数据库 在西北纪念医院(NMH)看到的癌症患者，杰西·布朗(前湖畔)退伍军人 事务医疗中心(VA)和埃文斯顿西北医疗(ENH)网站。创建的数据库为 对孢子来说是必不可少的，因为它提供了获得及时和高质量的特定信息的手段 关于孢子里的病人。制定了收集标准化数据集的程序， 从孢子的各个组成部分进行检查、编辑和输入。在下一个资助期内， 核心将扩展为合并芝加哥大学，将增加CDE的使用，合并 技术和软件来自NCI的caBIG倡议。生物统计学和生物信息学的核心 与临床试验和宣传核心以及样本采购核心广泛互动 孢子。核心之间的直接交互加快了数据组织、数据管理和数据 分析，使基于项目的团队能够流畅地创建孢子项目，将个人与 广泛的专业知识，并最大限度地提高孢子支助活动的效率。

The goals of the Biostatistics and Bioinformatics Core of the Prostate Cancer SPORE are (a) to maintain and continue to develop the clinical and tissue databases of the SPORE, (b) to provide experimental design, epidemiological and biostatistical expertise to all of the SPORE projects (c) to conduct data analysis and (d) to provide infrastructure and expertise for inter-SPORE and other scientific collaborations. The expertise of key members of this core facilitates planning, development and analysis of SPORE clinical trials, biomarker studies, molecular diagnostics and high throughput technologies such as DNA/RNA microarray, tissue microarray, proteomics experiments and retrospective studies. The SPORE Biostatistics and Bioinformatics Core leverages existing resources and expertise of the Biostatistics Shared Resource and the Bioinformatics Shared Resource of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. This enables the core to offer comprehensive bioinformatics and biostatistics services at minimal cost. During the past funding period, the Core has developed a fully operational, web-based, CDE-driven (common data element) central database for the SPORE that houses the clinical, tissue and laboratory data of prostate cancer patients seen at Northwestern Memorial Hospital (NMH), Jesse Brown (formerly Lakeside) Veterans Affairs Medical Center (VA), and Evanston Northwestern Healthcare (ENH) sites. The created database is essential to the SPORE as it provides means of obtaining timely and high quality specific information regarding patients in the SPORE. Procedures are in place whereby a standardized set of data are collected, checked, edited and entered from the various components of the SPORE. During the next funding period, the Core will expand to incorporate the University of Chicago, will increase the use of CDEs, incorporate technology and software coming from the NCI's caBIG initiative. The Biostatistics and Bioinformatics Core interacts extensively with the Clinical Trials and Advocacy Core and the Specimen Procurement Core of the SPORE. Direct interaction among the cores expedites data organization, data management and data analysis, enables the fluid creation of project-based teams for SPORE projects incorporating individuals with a broad range of expertise, and maximizes the efficiency of the SPORE-supported activities.