INGENUITY SOFTWARE FOR PATHWAY AND NETWORK ANALYSIS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这个基于网络的软件允许INBRE成员组装基因网络。该软件对使用微阵列或蛋白质组学的研究人员特别有用，因为该软件查询人类管理的数据库，以了解基因和蛋白质及其相互作用，以确定特定蛋白质是否已知相互作用。该软件还允许确定基因功能，并发现特定基因或蛋白质是否是典型途径的成员。该软件还有助于预测强制表达和基因敲除研究的结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This web-based software allows INBRE members to assemble networks of genes. The software is particularly useful to investigators using microarrays or proteomics as the software queries a human-curated database for knowledge about genes and proteins and their interactions to determine whether particular proteins are known to interact. The software also allows gene functions to be determined and to discover whether particular genes or proteins are members of canonical pathways. The software also is helpful in predicting the results of both forced expression and gene knockdown studies.