ANALYSIS OF 3D BREAST SURFACE DEFORMATION DURING MAMMOGRAPHIC COMPRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 刘凤山 乳腺摄影压迫过程中三维乳房表面变形分析 乳腺X线摄影是筛查无症状妇女早期乳腺癌的标准临床成像方式。 乳房压迫是乳房X线检查的重要组成部分，它会导致乳房相对变形。 在比较不同时间拍摄的乳房图像或使用各种模态拍摄的图像时，考虑这种变形非常重要。 在这个项目中，我们研究了乳房表面变形，表面力分布和所施加的乳房X线摄影压缩力之间的关系，这是必要的设计一个改进的乳房定位协议，旨在实现更舒适和更少的运动在乳房X线摄影。 该研究也可用于改进乳腺X线照片配准方法，以及用于改进乳腺组织建模和乳腺X线照片模拟。 该项目的具体目标包括：1。乳房压迫分析系统的开发; 2.使用物理模型评估压缩分析系统;以及3. 10-20名志愿者进行的乳房变形的初步临床研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fengshan Liu Analysis of 3D Breast Surface Deformation during Mammographic Compression Mammography is the standard clinical imaging modality for screening asymptomatic women for early breast cancer. Breast compression, which is an essential part of the mammographic exam, causes deformation of the breast relative. It is important to account for this deformation when comparing breast images taken at different times, or images using various modalities. In this project we study the relationship between the breast surface deformation, surface force distribution, and the applied mammographic compression force, which is necessary for designing an improved breast positioning protocol aimed at achieving more comfort and less motion during mammography. This study could also be used for improving mammogram registration methods, and for refinement of breast tissue modeling and mammography simulation. The specific aims of this project include: 1. Development of a breast compression analysis system; 2. Evaluation of the compression analysis system using physical phantoms; and 3. Pilot clinical study of breast deformation with 10-20 volunteers.