UNIVERSITY OF NEBRASKA AT OMAHA - BIOLOGY AND COMPUTER SCIENCE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 UNO生物学有三个INBRE同事，威廉·塔普里希，伊莱恩·拉休和唐纳德·罗恩。 塔普里希博士负责管理拨款。 Tapprich博士和Rowen博士是传染病主题的成员，Lahue博士是细胞信号主题的成员。 所有同事都向国际期刊提交了手稿，所有人的手稿都被接受出版。 Tapprich博士出版了两本出版物，一本是《微生物学和免疫学当前主题》，另一本是《病毒学杂志》。 罗文博士在《微生物学》杂志上发表了一篇论文。 Lahue博士有一个出版物在酵母接受。 所有的同事也在国家和国际会议上介绍他们的工作。 现在有六个BRIN学者在UNO生物学，丹雷默，扎卡里迈耶，乔尔里瓦斯，卡拉戈登，本汉泽尔和梅根纳尔逊。 前四名将于2005年5月毕业。 Dan和Zach已经被UNMC的医学院录取，Joel还没有决定他的未来计划，Kara将在攻读博士学位之前作为研究技术员工作一年。 所有目前的学者都积极参加并在国家和国际会议上介绍他们的研究工作。 卡拉和扎克是优秀专业部门奖的获得者，卡拉获得了今年的UNO优秀本科生奖。 三位新的学者被选为来年，马库斯芬奇，苔丝Eidem和莫纳Sorouri。 所有人都将开始在联合国监测委员会的夏季项目。 INBRE赠款提供的资金使我们能够在该部门建立一个DNA测序设施和一个定量真实的时间PCR设施。 来自INBRE赠款的供应和旅行资金在维持我们的研究计划方面是非常宝贵的，并直接导致了今年将出现的出版物。 UNO的计算机科学部门继续在生物信息学领域取得重大进展。生物信息学活动继续增长，五名教师（包括四名INBRE同事），十名研究生和二十名本科生在新开发的生物信息学课程（包括五名BRIN学者）的贡献。 INBRE的四位同事（Hesham Ali，Zhengxin Chen，Parvathi Chundi和Mark Pauley）在生物信息学的研究和教育活动中非常活跃。除了这四位同事之外，另一位计算机科学系的教授郭黑锋也表现出了兴趣，并在该领域进行了研究。 该小组的研究成果十分显著，其成果在几次专业会议上作了介绍，并在三份期刊上发表，还提交了许多会议记录。他们一直在指导一些研究生，包括五名博士生。此外，在生物信息学三个新的课程开发，并提供了最后两个学期。此外，一个新的生物信息学研究员，刘国庆，将加入UNO今年夏天之间的计算机科学和生物系的联合任命， 2004年的两名BRIN学者（Nicholas巴勒莫和Sarfraz Chandio）继续从事与去年夏天进行的项目有关的项目。在几次区域活动和两次国际会议上介绍了这些项目的成果。今年夏天，两位学者将继续在他们去年夏天加入的同一研究实验室开展活动。三名新的BRIN学者从七名申请者中选出，并将于今年夏天加入研究实验室。这三位学者都是UNO提供的生物信息学新学位的20名学生之一。新学位吸引了许多优秀学生，预计在未来几年内将迅速增长。 计算机科学系继续容纳一个重要的计算设施，该设施是由早期一轮BRIN赠款和NSF EPSCoR基础设施赠款的资金开发的。集群计算设施服务于生物信息学学生和教师的所有研究和教育需求。目前正在研究几种备选方案，以更新和维护这些设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. UNO biology has three INBRE associates, William Tapprich, Elaine Lahue and Donald Rowen. Dr. Tapprich administers the grant. Drs. Tapprich and Rowen are members of the infectious disease theme and Dr. Lahue is a member of the cell signaling theme. All associates have submitted manuscripts to international journals and all have had their manuscripts accepted for publication. Dr. Tapprich has two publications in press, one in Current Topics in Microbiology and Immunology and one in Journal of Virology. Dr. Rowen has a publication accepted in Microbiology. Dr. Lahue has a publication accepted in Yeast. All of the associates are also presenting their work at national and international meetings. There are now six BRIN scholars in UNO biology, Dan Reimer, Zachary Meyer, Joel Rivas, Kara Gordon, Ben Hanzel, and Megan Nelson. The first four will be graduating in May 2005. Dan and Zach have been accepted into medical school at UNMC, Joel is still undecided about his future plans and Kara will work for a year as a research technician before pursuing a Ph.D. All of the current scholars have been active in attending and presenting their research work at national and international meetings. Kara and Zach were recipients of the departmental awards for outstanding major and Kara received this year's award as the outstanding undergraduate at UNO. Three new scholars have been selected for the coming year, Marcus Finch, Tess Eidem and Mona Sorouri. All will begin summer projects at UNMC. Funds made available from the INBRE grant enabled us to establish a DNA sequencing facility and a quantitative real time PCR facility in the department. Supply and travel funds from the INBRE grant are invaluable in maintaining our research programs and have led directly to the publications that will appear this year. The computer science department at UNO continues to develop significantly in the area of Bioinformatics. The Bioinformatics activities are continuing to grow with the contribution of five faculty members (including four INBRE associates), ten graduate students and twenty undergraduate students in the newly developed Bioinformatics programs (including five BRIN scholars). The four INBRE associates (Hesham Ali, Zhengxin Chen, Parvathi Chundi and Mark Pauley) have been very active in leading research and educational activities in Bioinformatics. In addition to the four associates, another computer science faculty member, Heifeng Guo, has shown interest and has conducted research in the field. The research output of the group has been significant, with results presented in several professional meetings and published in three journals and many referred conference proceedings. They have been supervising a number of graduate students including five doctoral students. Additionally, three new courses in Bioinformatics were developed and offered the last two semesters. Also, a new Bioinformatics researcher, Guoqing Liu, will be joining UNO this summer on a joint appointment between the departments of Computer Science and Biology, The two 2004 BRIN (Nicholas Palermo and Sarfraz Chandio) Scholars continued to work on projects related to the ones conducted last summer. The results of the projects were presented in several regional events as well as in two international conferences. This summer, both scholars will continue their activities at the same research labs they joined last summer. Three new BRIN Scholars were selected from seven applicants and will join research labs this coming summer. All three scholars are among the 20 students on the new degree in Bioinformatics offered at UNO. The new degree has been attracting many outstanding students and is expected to grow rapidly in the next couple of years. The computer science department continues to house a significant computational facility that was developed by funds from an earlier round of the BRIN grant and an NSF EPSCoR infrastructure grant. The cluster computing facility serves all research and educational needs of the Bioinformatics students and faculty. Several options are currently been investigated to upgrade and maintain the facilities.