POSTMORTEM HUMAN BRAIN COLLECTION CORE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尽管现代脑成像在活体患者和许多精神疾病动物模型中有好处，但对死后实际脑组织的分析总是有很大的需求。对死后组织的研究可以集中在单个神经元及其辅助细胞，神经胶质细胞，以评估细胞解剖特征，蛋白质表达以及与其他单个神经细胞的相互作用，从而揭示无法从活体患者或动物模型中获得的信息。 CPN人类大脑收集核心由克雷格A博士指导。斯托克梅尔，核心领袖。Stockmeier博士在开发和管理国内领先的专门用于精神神经科学的死后人脑收藏方面拥有丰富的经验。人脑收藏由国家精神卫生研究所从1989年到2007年资助，并由NCRR从2007年到2012年资助。 大脑收集是与俄亥俄州克利夫兰凯斯西储大学精神病学和心理学系以及俄亥俄州克利夫兰凯霍加县验尸官办公室合作进行的。精神病评估小组包括詹姆斯C。Overholser博士和医学博士乔治·J·尤尔尤斯。Overholser博士是一位临床心理学家，长期以来一直对青少年和成年人的抑郁症感兴趣。Jurjus博士是克利夫兰韦德公园VA医院住院精神病学和康复主任，自1997年以来一直是回顾性诊断小组的一员，并提供精神活性物质使用障碍方面的额外专业知识。 博士Stockmeier和他的合作者组织了大脑收集的所有方面，包括组织样本和伴随的临床信息的存储。CPN项目的主要研究者获得了高质量的死后人脑样本，这些样本符合其涉及精神疾病的研究目标的入选标准，以及脑组织的关键支持信息。Stockmeier博士还建议CPN研究人员选择和匹配适当的对照和精神病受试者进行生物学研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the benefits of modern brain imaging in living patients and the numerous animal models of psychiatric illness, there will always be a significant need for the analysis of actual brain tissue postmortem. Studies on postmortem tissues can zero in on individual neurons and their helper cells, neuroglia, to assess cellular anatomic features, protein expression and interactions with processes from other individual nerve cells revealing information not attainable from living patients or animal models. The CPN Human Brain Collection Core is directed by Dr. Craig A. Stockmeier, Core Leader. Dr. Stockmeier has extensive experience in the development and management of one of the leading postmortem human brain collections in the country devoted specifically to psychiatric neuroscience.The Human Brain Collection was funded by the National Institute of Mental Health from 1989 through 2007 and is funded by NCRR from 2007 through 2012. The brain collection is run in collaboration with the Departments of Psychiatry and Psychology, Case Western Reserve University, Cleveland, Ohio, and with the Cuyahoga County Coroner Office, Cleveland, Ohio. The psychiatric assessment team includes James C. Overholser, Ph.D. and George J. Jurjus, M.D. Dr. Overholser, a clinical psychologist, has a long-standing career interest in depressive disorders in adolescents and adults. Dr. Jurjus, Director of Inpatient Psychiatry and Detoxification at the Cleveland Wade Park VA Hospital, has been part of the retrospective diagnostic team since 1997 and provides additional expertise in psychoactive substance use disorders. Dr. Stockmeier and his collaborators organize all aspects of the brain collection, including storage of tissue samples and accompanying clinical information. CPN Project Principal Investigators are provided with high-quality postmortem human brain samples meeting inclusion criteria for their research aims involving psychiatric illnesses, as well as the critical supporting information for the brain tissue. Dr. Stockmeier further advises CPN investigators in the selection and matching of appropriate control and psychiatric subjects for their biological studies.