TULANE COBRE: TRANSGENIC & GENE-TARGETED ANIMAL CORE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 转基因和基因靶向动物核心设施作为维护和研究基因工程小鼠和大鼠品系的宝贵资源，将有助于理解高血压的病理生理学和调节血压和心血管疾病状态的分子机制。该设施将为研究人员提供独特的资源和标准化的方法来表征转基因和基因靶向小鼠。总体而言，动物核心提供了独特的最先进的标准化方法，以进一步表征新型转基因和基因靶向小鼠模型，以研究血压调节和心血管稳态。该核心有助于支持初级教师调查人员以及几位高级导师和博士后研究员的项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The transgenic and gene-targeted Animal Core Facility serves as a valuable resource for the maintenance and study of genetically engineered mouse and rat strains that will contribute to the understanding of the pathophysiology of hypertension and the molecular mechanisms regulating blood pressure and cardiovascular disease states. This facility will provide investigators access to unique resources and standardized methods to characterize transgenic and gene-targeted mice. Overall, the animal core provides access to unique state-of-the-art standardized methods to further characterize the novel transgenic and gene-targeted mouse models to study the blood pressure regulation and cardiovascular homeostasis. The core helps support projects from junior faculty investigators as well as several of the senior mentors and postdoctoral fellows.