MEDICINAL CHEMISTRY OF STEROIDS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们对类固醇的化学和生物学感兴趣。我的实验室专门研究天然产物化学，因为它与类固醇和类固醇类似物的合成有关。然后，在实验室中制备的化合物在整个大学和其他地方的同事的实验室中进行研究，他们与我们对类固醇的生物作用有共同的兴趣。目前，我们的努力集中在三个主要领域：神经活性类固醇；神经保护性类固醇；以及胆固醇和胆汁类固醇动态平衡。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the chemistry and biology of steroids. My laboratory specializes in natural products chemistry as it relates to the synthesis of steroids and steroid analogues. The compounds prepared in the laboratory are then studied in laboratories of colleagues throughout the university, and elsewhere, who share with us a common interest in the biological actions of steroids. Currently our efforts are focused in three main areas: neuroactive steroids; neuroprotective steroids; and cholesterol and bile steroid homeostasis.