CREATINE KINASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肌酸激酶(CK)催化肌酸和三磷酸腺苷的可逆转化为磷酸肌酸和二磷酸腺苷，从而帮助维持细胞内的能量平衡。我们已经有了带有三磷酸腺苷的鱼雷加利福尼亚肌酸激酶结构及其过渡态类似物(CK-TSAC)。我们现在正在尝试解决载脂蛋白的形式，并研究其结构的相对变化。 人类有三种同工酶，即：MM、MB和BB存在于肌肉、心脏和脑组织中。在心肌梗死的情况下，CK-MB水平会升高，这就是所测量的。我有带有TSAC的CK-MB的晶体，需要收集它的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Creatine kinase (CK) catalyzes the reversible conversion of creatine and ATP to phosphocreatine and ADP, thereby helping maintain energy homeostasis in the cell. We already have the structure of Torpedo californica Creatine Kinase structure with ATP and its transition-state analogue complex (CK-TSAC). We now are trying to solve the apo form and study the relative change in structure. There are three isoenzymes present in human, namely : MM, MB, and BB are found in muscle, cardiac and brain tissues. The level of CK-MB rises in case of Myocardial Infarction and that is what is measured.I have the crystals of the CK-MB with TSAC and need to collect data on it.