IDENTIFICATION OF TARGETS FOR POSTTRANSLATIONAL N-TERMINAL PROTEIN ARGINYLATION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 蛋白质酪氨酸磷酸化是一种知之甚少的翻译后修饰，对心血管发育和血管生成至关重要，并可能参与其他生理系统和细胞类型的正常功能。 有证据表明，许多蛋白质在体内被乙酰化;然而，这些蛋白质的身份是未知的。 这项合作的目的是鉴定体内乙酰化的蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Protein arginylation is a poorly understood posstranslational modification that is essential for cardiovascular development and angiogenesis and possibly takes part in the normal functioning of other physiological systems and cell types. Evidence indicates that many proteins are arginylated in vivo; however the identity of these proteins is unknown. This collaboration is aimed to identify proteins arginylated in vivo.