IDENTIFICATION OF TARGETS FOR POSTTRANSLATIONAL N-TERMINAL PROTEIN ARGINYLATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 蛋白质精氨酸化是一种鲜为人知的翻译后修饰，对心血管发育和血管生成至关重要，并可能参与其他生理系统和细胞类型的正常功能。有证据表明，许多蛋白质在体内是精氨酸化的；然而，这些蛋白质的身份尚不清楚。这项合作的目的是识别体内精氨酸化的蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Protein arginylation is a poorly understood posstranslational modification that is essential for cardiovascular development and angiogenesis and possibly takes part in the normal functioning of other physiological systems and cell types. Evidence indicates that many proteins are arginylated in vivo; however the identity of these proteins is unknown. This collaboration is aimed to identify proteins arginylated in vivo.