WHITE MATTER ARCHITECTURE FROM DIFFUSION MRI

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 白色物质架构核心的首要目标是追求技术 提高对白色物质解剖学理解的发展。等 特别是由于神经通路相对于当前成像分辨率的小尺寸，理解对于开发用于分析解剖结构的新方法和技术以及将这些分析应用于理解神经疾病是至关重要的。该信息自然地补充了从标准结构分析获得的图谱信息。 临床目的是检测和定位白色脑异常， 精神分裂症使用扩散MRI和后处理成像技术，虽然我们 我希望所开发的方法将适用于广泛的白色物质 疾病为了解决白色物质结构和异常的问题，我们 开发了一种新技术，用于分析白色物质沿着工具，用于3D扩散MRI数据的可视化和交互式探索。除了支持该核心的特定需求外，这些工具还直接应用于早期检测发育中的婴儿大脑中的白色物质损伤;探索和表征由MS病变引起的白色物质破坏;以及在神经外科手术期间重要的白色物质纤维束的可视化（例如，连接运动皮质和脊髓下部运动中心的皮质脊髓束。）

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overarching goal of the White Matter Architecture core is to pursue technological developments that improve the understanding of white matter anatomy. Such understanding, particularly owing to the small dimension of the neural pathways relative to current imaging resolution, is vital to developing novel methods and techniques for the analysis of anatomical structures, and for the application of those analyses to understanding neural diseases. This information naturally complements atlas information obtained from standard structural analysis. The clinical objective is to detect and localize white matter brain abnormalities in schizophrenia using techniques in diffusion MRI and post-process imaging, although we expect that the methods developed will be applicable to a broad range of white matter disease. To address the issue of white matter structure and abnormalities, we have developed a new technology for analyzing white matter along with tools for visualization and interactive exploration of 3D diffusion MRI data. In addition to supporting the specific needs of this core, these tools have been applied directly to the early detection of white matter damage in the developing infant brain; exploration and characterization of white matter disruptions caused by MS lesions; and visualization of important white matter fiber tracts during neurosurgical procedures (e.g., the cortical spinal tract connecting the motor cortex with the lower motor centers of the spinal cord.)