ASYNCHRONY OF BOLD SIGNAL ACROSS BRAIN REGIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 功能磁共振成像测量的神经激活的血流动力学反应在不同的脑区具有不同的特征。以前的工作表明，不同的大脑区域或层可以表现出不同的血液动力学反应，但还没有对整个大脑的这种差异进行系统的研究。 具体目标： 为了研究BOLD信号的时间方面，即BOLD信号在不同大脑区域的异步性(超前-滞后)， 方法： 我们使用相关图来量化在解剖学自动标记中预先定义的90个区域中每两个大脑区域之间的领先或滞后，在一个约1000名受试者的大数据集中，跨越10个不同的fMRI实验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The hemodynamic response of neural activation as measured by fMRI has different characteristics across different brain regions. Previous work has shown that different brain regions or layers can show different hemodynamic response, but there is no systematic investigation of such difference across the entire brain. Specific Aims: To study the temporal aspect of BOLD signal; that is, the asynchrony (lead-lag) of BOLD signal across different brain regions, Methods: We used correlogram to quantify the lead or lag between every two brain regions from 90 regions predefined in Anatomical Automatic Labeling in a large dataset of about 1000 subjects crossing 10 different fMRI experiments.