VISUALIZATION ENVIRONMENTS FOR MULTI-SCALE BIOMEDICAL MODELING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目标是开发一个基于组件的可视化环境，这是有用的，以各种规模和各种数据类型的分子结构功能关系方面的生物科学家的广泛工作。该环境支持从基因序列和原子细节结构到电子显微镜和光学显微镜重建的数据的结构信息。随着基因组计划扩展到功能基因组学领域，越来越需要整合生物物理范围内的数据和计算的可视化工具。从序列数据、单个分子结构和生物样品成像开发复杂模型的可能性将取决于支持多模式和多尺度能力的计算和可视化环境。通过利用NPACI计划中正在开发的基于组件的交互基础设施，我们将能够有效地设计和构建可视化工具，这些工具是针对计算生物学社区不断增长的需求而量身定制的，并且将集成到基于网络的计算和协作环境中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to develop a component-based visualization environment that is useful to a broad range of biological scientists working on aspects of molecular structure function relationships at various scales and with a variety of data types. The environment supports structural information that ranges from gene sequence and structure at atomic detail, to data reconstructed from electron microscopy, and light microscopy. As the Genome Initiative expands into the area of functional genomics, there is an increasing need for visualization tools that integrate data and computation from across the biophysical range. The possibility of developing complex models from sequence data, individual molecular structures, and imaging of biological samples will depend upon computational and visualization environments that support multi-modal and multi-scale capabilities. By capitalizing on the component-based interaction infrastructure being developed within the NPACI program, we will be able to efficiently and effectively design and build visualization tools that are tailored to the growing needs of the computational biology community, and that will integrate into network based computational and collaborative environments.