MECHANOELECTRIC FEEDBACK IN CARDIAC DEFIBRILLATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心脏颤动是心脏杂乱无章的电行为，其后果是失去协调的肌肉收缩。通过及时对心脏施加强烈电击的电除颤，长期以来一直被用作这种否则致命的心律失常的有效治疗方法。近年来，由于除颤治疗的可及性和功能性的改善，除颤治疗已显着扩大。尽管这项技术在拯救人类生命方面发挥了关键作用，但电击阻止危及生命的心律紊乱的基本机制尚不完全清楚。 机械收缩伴随着心脏的电活动。然而，人们很早就知道，在抗心律失常治疗中，电过程和机械过程之间存在着串扰。由于心脏结构和行为的复杂性，以前在心脏除颤机制的研究中从未考虑过机械作用。本研究的目的是确定机械电反馈在心脏除颤过程中的作用，从而增加我们对心脏暴露在强电刺激下终止纤颤的机制的了解。该应用程序寻求在杜兰大学的计算心脏电生理学小组和国家生物医学计算资源之间建立合作，从而充分利用这两个小组分别开发的建模心脏除颤和机械收缩的最先进方法的组合。该项目完成后，预计将为如何利用心脏中复杂的机电事件来帮助抗心律失常治疗带来新的理解水平。作为NBCR的一个合作项目，这项研究将促进连续性及其解剖、电气和机械模型和算法的扩展，使其能够与心脏和躯干的双项模型更好地集成，从而打开心脏起搏、休克和心电图学中的大量应用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiac fibrillation is disorganized electrical behavior of the heart, and its consequence is the loss of coordinated muscle contraction. Electrical defibrillation by timely application of a strong electric shock to the heart has long been used as an effective therapy for this otherwise lethal disturbance of cardiac rhythm. In recent years defibrillation therapy has dramatically expanded due to its improved accessibility and functionality. Despite the critical role that the technique plays in saving human life, the fundamental mechanisms by which electrical shocks halt life-threatening disturbances in cardiac rhythm are not completely understood. Mechanical contraction follows the electrical activation of the heart. However, it has long been known that there is a cross-talk between the electrical and mechanical processes which could play a role in anti-arrhythmia therapy. Owing to the complexities in cardiac structure and behavior, mechanical contributions have never before been considered in the investigation of cardiac defibrillation mechanisms. The objective of this research is to determine the contribution of mechanoelectrical feedback in the process of cardiac defibrillation, and thus, to increase our knowledge of the mechanisms by which the exposure of the heart to strong electric shocks terminates fibrillation. This application seeks to establish collaboration between the Computational Cardiac Electrophysiology Group at Tulane University and the National Biomedical Computation Resource and thus, to take full advantage of the combination of state-of-the-art approaches in modeling cardiac defibrillation and mechanical contraction, respectively, developed by the two groups. Upon completion, the project is expected to bring a new level of understanding to how the complex electro-mechanical events in the heart can be used to benefit anti-arrhythmia therapy. As a collaborative project of the NBCR this research will promote extensions to the development of Continuity and its anatomic, electrical and mechanical models and algorithms that will permit greater integration with bidomain models of the heart and torso, opening in up to the large array of applications in cardiac pacing, shock and electrocardiography.