HYPERPOLARIZED 3HE MR - LUNG CANCER LESIONS TAGGED BY TARGETED SPIONS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 沃伦集团与路易斯安那州立大学的Carola Leuschner长期合作，开发超顺磁性氧化铁纳米颗粒（SPION）以靶向癌症。一个具体的兴趣是开发靶向转移性肺癌的SPION。这已经通过组织学技术实现和证明。随后的目标是成像 体内存在这种转移。这是一个具有挑战性的目标，因为SPIONS的主要对比度是降低T2*，但肺质子已经具有非常短的T2*，使得这种效果无法观察到。然而，通过使用3 He MRI缓解了该问题，因为3 He具有T2* > 15 ms，因此留下足够的动态范围用于观察靶向转移区域中的T2* 降低。 我们在该试点项目中的具体目标是进行初步可行性研究，以测试3 He MRI是否可以用于检测Warren组提供的小鼠模型中的肺癌转移。如果我们成功地获得了这些初步的体内数据，它将被转化为赠款申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Warren Group has a long-term collaboration with Carola Leuschner of LSU to develop super paramagnetic iron oxide nanoparticles (SPIONs) to target cancer. A specific interest is to develop SPIONS that target metastatic lung cancer. This has been achieved and demonstrated by histologic techniques. A subsequent goal is to image the presence of such metasteses in vivo. This is a challenging goal because the primary contrast from SPIONS is to reduce T2*, but lung protons already have very short T2* rendering this effect unobservable. However, this problem is mitigated by using 3He MRI since 3He has a T2* > 15 ms, therefore leaving ample dynamic range for observing T2* reduction in areas of targetted metasteses. Our specific aims in this pilot project are to perform a preliminary feasibility study to test whether 3He MRI can be used to detect lung cancer metastases in mouse models supplied by the Warren group. If we are successful in obtaining this preliminary in vivo data, it would be translated into a grant application.