MENDELIAN RANDOMIZATION TO INFER CAUSATION IN OBSERVATIONAL EPIDEMIOLOGY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目前，人们对扭曲的机制知之甚少。 等位基因的分布与孟德尔的预期分布不同 配子形成、受孕、出生和产卵之间的第一定律 进入一项研究。因此，很难估计其程度。 这些机制可能会影响孟德尔的结果 随机研究。然而，这些机制不应该 在它们被适当地处理之前被认为是可以忽略的 已评估。有可能扭曲隔离，有选择地生存 并且在以下情况下应牢记原产地效应 进行孟德尔随机化研究得出因果关系 观察性研究中的推理。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, little is known about the mechanisms that distort the distribution of alleles from that expected from Mendel's first law between gamete formation, conception, birth and entry into a study. It is therefore difficult to estimate the extent to which these mechanisms may affect the results of Mendelian randomization studies. However, these mechanisms should not be assumed to be negligible until they have been properly evaluated. Potential for segregation distortion, selective survival and parent-of-origin effect should be kept in mind when conducting Mendelian randomization studies to draw causal inference in observational studies.