DYNAMICS AND CEREBRAL SOURCES OF ATTENTIONAL PROCESSES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们认为注意是一种结构，它包括三类相互关联的动态过程：1)参与注意力重定向的过程，2)根据注意焦点选择性地处理信息的过程，3)参与维持注意焦点的过程。由于这些过程的动态性质，研究潜在的大脑机制需要分析活跃的大脑区域及其时间激活模式。通过我们在前一个资助期的进展和合作项目，我们有能力获得脑电(EEG)、脑磁图(MEG)、脑解剖磁共振图像(MRI)和功能磁共振成像(FMRI)，以及在我们的实验室集成和分析这些多模式数据的能力。这使得我们能够改进我们的方法来估计EEG和MEG的脑部来源，包括表征这些脑区的时间激活模式。我们现在有能力用解剖MRI来限制EMSE，并用相同受试者的fMRI数据来通知可能的脑来源的位置。功能磁共振成像还可以作为一种独立的功能神经成像方法，用于探索与注意力有关的大脑系统。拟议的项目应用这种综合的多学科方法来检查参与这些注意过程的大脑区域的空间分布，并表征所涉及的大脑系统的时间动力学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We consider attention to be a construct which includes three interrelated classes of dynamic precesses: 1) those involved in redirecting attention, 2) those which selectively process information according to the focus of attention, and 3) those which are involved in sustaining the focus of attention. Due to the dynamic nature of these processes, investigation of the underlying brain mechanisms requires analyses of the active brain regions and their temporal activation patterns. Through our progress in the preceding grant period and through collaborative projects, we have the ability to acquire electroencephalography (EEG), magnetoencephalography (MEG), brain anatomical magnetic resonance images (MRI) and functional MRI (fMRI); as well as the capability to integrate and analyze these multi-modal data in our laboratory. This has enabled us to improve our methods for electromagnetic source estimation (EMSE) of the brain sources of EEG and MEG, including characterization of the temporal activation patterns in these brain areas. We now have the ability to constrain the EMSE with anatomical MRI and to inform the locations of likely brain sources with fMRI data in the same subjects. fMRI also serves as a stand-alone functional neuroimaging method for exploring the brain systems involved in attention. The proposed project applies this integrated multidisciplinary approach to examination of the spatial distribution of brain areas involved in these attentional processes and characterization of the temporal dynamics of the brain systems involved.