PATHWAYS LINKING REDUCED SLEEP DURATION AND QUALITY TO OBESITY RISK

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的总体目标是获得将睡眠不足或睡眠质量降低与特定中枢神经系统和调节能量摄入的外周通路的变化联系起来的因果证据。正常的年轻人将在三个精心控制的实验室条件下进行研究，包括4天不受干扰的睡眠(在床上8.5小时；“基线”)，4天的短不受干扰的睡眠(在床上4.5小时；“短睡眠”)和4天的SWS实验抑制(在床上8.5小时；“SWS睡眠抑制”)。在“短睡眠”和“SWS抑制”状态之后，将进行2晚的无干扰恢复睡眠，在床上休息9个小时。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our overall goal is to obtain causative evidence linking short sleep or reduced sleep quality, to alterations in specific central nervous system and peripheral pathways regulating energy intake. Normal young adults will be studied under three carefully controlled laboratory conditions with 4 days with undisturbed sleep (8.5hrs in bed; "baseline"), 4 days with short undisturbed sleep (4.5 hrs in bed; "short sleep") and 4 days of experimental suppression of SWS (8.5 hrs in bed; "SWS sleep suppression"). Both the "short sleep" and "SWS suppression" conditions will be followed by 2 nights of undisturbed recovery sleep with 9 hours in bed.