Research Programs-Molecular Virology

分子病毒学基础研究计划(MVBRP)是一个跨学科的基础研究计划 由17个独立但互动的实验室组成，他们对分子生物学和 与癌症及相关主题相关的病毒免疫学。该计划的总体目标是促进 研究病毒致癌的基本机制和病毒免疫学；进行调查 这可能会导致新的方法来预防或治疗与病毒相关的肿瘤；或使用病毒 作为疫苗或溶瘤剂。在Daniel DiMaio，医学博士的领导下，一种肿瘤 病毒学家，主要研究乳头瘤病毒，MVBRP主要通过赞助 分子病毒学和肿瘤学小组会议和史蒂文·德加纪念讲座，由 鼓励和鼓励合作研究，并通过提供获得YCC资金和共享 资源。DiMaio博士与其他项目教员一起，指导研究生水平的课程--分子 动物病毒生物学。他也是NCI资助的项目资助项目的首席研究员， 病毒和细胞转化的分子基础，以及美国国立卫生研究院资助的博士后培训补助金 肿瘤病毒学和NIAID资助的病毒学博士前培训补助金。这所大学的杰出教师 该计划包括国家科学院(Steitz)和医学研究所(Miller)的成员 和斯泰茨)。该计划的成员总共获得了七项NIH优异奖。现在有 在基础肿瘤病毒学、疫苗开发和病毒免疫学领域作出重大努力；以及 溶瘤病毒。在上一次资助期间，该计划的成员发表了243篇与癌症有关的论文，其中 其中4.1%是方案内的，18%是方案间的。因为病毒在病毒感染中起着因果作用。 很大一部分人类肿瘤，在该计划中进行的研究最终可能会有重要的 通过揭示病毒复制和治疗的机制对癌症预防和治疗的影响 肿瘤发生，从而确定新的翻译努力的目标。此外，这些研究将揭示 与许多疾病的发生和治疗有关的生物现象的机制基础 癌症，包括那些与病毒无关的癌症。分子病毒学项目目前有18个 来自12个部门的成员，研究经费总额为720万美元直接费用(总计1060万美元 费用)，其中630万美元的直接费用由同行审查，270万美元的直接费用由NCI资助。

The Molecular Virology Basic Research Program (MVBRP) is an interdisciplinary basic research Program consisting of 17 independent but interactive laboratories with common interests in the molecular biology and immunology of viruses relevant to cancer and related topics. The overall goal of this Program is to facilitate research into the basic mechanisms of viral tumorigenesis and viral immunology; to conduct investigations that may lead to novel approaches to prevent or treat tumors associated with viruses; or to use viruses themselves as vaccines or oncolytic agents. Under the leadership of Daniel DiMaio, M.D., Ph.D., a tumor virologist who focuses on papillomaviruses, the MVBRP accomplishes these goals primarily by sponsoring the Molecular Virology and Oncology Group Meetings and the Steven Degar Memorial Lectureship, by encouraging and stimulating collaborative research, and by providing access to YCC funds and shared resources. Dr. DiMaio, along with other Program faculty, directs the graduate level course, The Molecular Biology of Animal Viruses. He is also the Principal Investigator of the NCI-funded Program Project Grant, Molecular Basis of Viral and Cellular Transformation, as well as an NCI-funded postdoctoral training grant in tumor virology and an NIAID-funded predoctoral training grant in virology. The distinguished faculty of this Program includes members of the National Academy of Sciences (Steitz) and the Institute of Medicine (Miller and Steitz). In aggregate, the Program members have received seven NIH MERIT Awards. There are now substantial efforts in the areas of basic tumor virology, vaccine development and viral immunology, and oncolytic viruses. In the last grant period, members of this Program published 243 cancer related papers, of which 4.1% were intra-programmatic and 18% inter-programmatic. Because viruses play a causal role in a substantial fraction of human tumors, studies carried out in this Program may eventually have an important impact on cancer prevention and treatment by revealing the mechanisms responsible for viral replication and tumorigenesis, thus identifying novel targets for translational efforts. In addition, these studies will reveal the mechanistic basis of biological phenomena that are relevant to the development and treatment of many cancers, including those not associated with viruses. The Molecular Virology Program currently has 18 members from 12 departments, with total research funding of $7.2 million direct costs ($10.6 million total costs), of which $6.3 million direct costs is peer-reviewed and $2.7 million direct costs is NCI-funded.