Small Animal Imaging

UWCCC小动物成像设备提供创新的、最先进的、负担得起的、非侵入性的 为使用小动物模型的UWCCC成员提供高分辨率的体内和体外成像支持 他们的研究。设施主任和经理与调查人员就以下事项提供咨询 最适合回答他们的生物学问题的方法。调查人员能够选择各种不同的 支持级别从仅获取图像，到获取和重建，再到图像 首先是口译，最后是媒体展示。由于他们的放射化学专业知识，他们还 放射标记小分子或蛋白质，供研究人员在成像前使用。 解剖显微CT扫描。西门子/CTI的MicroCAT-2配备了大视场 探测器，从而允许高分辨率扫描(18微米)高达300克的老鼠。该系统配备 带有啮齿动物异氟醚气体麻醉系统和生理监测系统，允许图像 门控， 功能性microPET扫描。也可以使用功能性的microPET成像。因为两台扫描仪 来自同一家制造商，扫描床完全可互换，从而允许扫描 在不移动动物的情况下使用两种模式，从而允许相当准确地融合两个数据集。 我们计划于年从西门子/CTI公司获得第一台商用microCT/microPET混合扫描仪 2006年6月。这是世界上第一台混合扫描仪，配有我们自己的专有细胞选择性成像和 造影剂为我们的研究人员提供了独特的肿瘤检测和评估技术，只有 在这里提供。

The UWCCC Small Animal Imaging Facility provides innovative, state-of-the-art, affordable, noninvasive, high-resolution in-vivo and ex-vivo imaging support to UWCCC members who utilize small animal models in their research. The facility director and manager provide consultation with investigators about methodologies most suited to answer their biological questions. Investigators are able to select various levels of support ranging from image acquisition alone, to acquisition and reconstruction, to image interpretation and finally to media presentation. Because of their radiochemistry expertise, they also radiolabel small molecules or proteins for investigators prior to imaging. Anatomic MicroCT Scanning. A MicroCAT-2 from Siemens/CTI is equipped with a large field-of-view detector, thus allowing high resolution scanning (18 micron)'of rats up to 300 grams. The system is equipped with a rodent isoflurane gas anesthesia system and physiologic monitoring system which allows image gating, Functional MicroPET Scanning. Functional microPET imaging is also available. Because both scanners are from the same manufacturer, the scanning beds are completely interchangeable which allows scanning with both modalities without moving the animal, thus allowing fairly accurate fusion of the two data sets. We are scheduled to acquire the first commercial microCT/microPET hybrid scanner from Siemens/CTI in June of 2006. This world's first hybrid scanner coupled with our own proprietary cell-selective imaging and contrast agents affords our investigators unique tumor detection and evaluation technologies which can only be provided here.