Endotoxin-induced Uveitis Revisited

葡萄膜炎是导致失明的主要原因。前葡萄膜炎的发病率大约是后葡萄膜炎的四倍 葡萄膜炎。内毒素诱导的葡萄膜炎是近30年前由PI首次描述的一种模型，它是一种 这是了解葡萄膜前道急性炎症的宝贵工具。在过去的十年里， 对内毒素引起的炎症的理解随着内毒素引起的炎症的特征而发生了革命性的变化 TLR4受体与内毒素激活的细胞内通路的整合阐明。它是 显然，将这种对内毒素相关影响的新理解与前部 葡萄膜道。因此，我们建议1)确定虹膜/睫状体中的相对重要性 已知可由内毒素激活的两条细胞内通路MyD88和TRIF和2)比较和 小鼠玻璃体内注射内毒素后内毒素耐受现象的对比研究 而不是腹膜内注射。这些拟议的研究将拓宽内毒素影响的知识。 在眼睛上。未来的研究可以建立在这些观察的基础上，以测试由 内毒素，因为这些分子在治疗葡萄膜炎和其他炎症方面有潜在的用处。

Uveitis is a major cause of blindness. Anterior uveitis is approximately four times as common as posterior uveitis. Endotoxin-induced uveitis, a model first described by the PI nearly 30 years ago, has been a valuable tool to understand acute inflammation in the anterior uveal tract. In the last decade, the understanding of endotoxin-induced inflammation has been revolutionized with the characterization of the TLR4 receptor and the e merging clarification of the intracellular pathways activated by endotoxin. It is obviously critically important to relate this new understanding of endotoxin-related effects to the anterior uveal tract. Consequently we propose to 1) determine the relative importance in the iris/ciliary body of the two intracellular pathways known to be activated by endotoxin, MyD88 and TRIF and 2) compare and contrast the phenomenon of endotoxin tolerance when endotoxin is injected into mice intravitreally as opposed to intraperitoneally. These proposed studies will broaden the knowledge of the effects of endotoxin on the eye. Future studies can buil d on these observations to test anti-inflammtory molecules induced by endotoxin as these molecules are potentially useful in the treatment of uveitis and other inflammations.