Training Programs in Cancer Pharmacology

描述（由申请人提供）：本申请旨在建立一个多学科的癌症药理学培训项目（CPTP），为博士生和博士后提供一个目前在凯斯西储大学不存在的培训机会。在不久的将来，癌症治疗和预防的重大进展将来自多学科方法，以阐明肿瘤发生和发展的基础过程，并制定和实施新的治疗和预防癌症的策略。该计划的目标是教授癌症药理学的基础知识，并培养学生涉及多学科互动的癌症药理学方法。因此，该项目将有助于填补目前能够在不同学科之间自由移动的个人的短缺，并与来自不同领域的科学家进行富有成效的互动，以开发下一代化疗药物。这些目标将通过提供的课程和教师提供的多学科研究经验来实现。项目主任Noa Noy和咨询委员会将在癌症药理学领域的多学科环境中为博士前和博士后科学家的招聘和培训提供持续的领导。35位具有不同互补专业知识的教师导师将分为四个子项目：癌症生物学，癌症药物设计和递送，成像和癌症系统生物学。每个受训者将有来自其中两个项目的研究导师。这个项目的导师们作为癌症研究人员有着非常出色的成就记录。他们是76项NIH拨款的首席研究员或项目负责人。除了培训经费外，29位导师还获得了nih资助（主要通过NCI）的研究经费。10年来，导师培养博士生210名，博士后192名；现有在读博士生126人，博士后111人。

DESCRIPTION (provided by applicant): This application proposes to develop a multidisciplinary Cancer Pharmacology Training Program (CPTP) to provide predoctoral and postdoctoral trainees with a training opportunity that does not currently exist at Case Western Reserve University. Major advances in the treatment and prevention of cancer in the near future will emerge from multidisciplinary approaches to elucidating the processes that underlie tumor initiation and progression and to developing and implementing novel strategies for therapy and prevention of cancer. The goals of the program are to teach the fundamentals of cancer pharmacology, and to train students in approaches to cancer pharmacology that involve multidisciplinary interactions. The program will thus help fill the current deficit of individuals who can move freely between disciplines and productively interact with scientists from various areas to develop the next generation of chemotherapeutic agents. These goals will be accomplished through the courses that are offered and the multidisciplinary research experiences that will be available from the faculty. The program director, Noa Noy, and the advisory committee will provide the sustained leadership required for the recruitment and training of both predoctoral and postdoctoral scientists in the multidisciplinary environment of the field of cancer pharmacology. The 35 faculty mentors with diverse complementary expertise will be grouped into four sub-programs: Cancer biology, Cancer Drug Design and Delivery, Imaging, and Cancer Systems biology. Each trainees will have research mentors from two of these programs. The mentors on this proposed program have a very strong record of accomplishment as cancer researchers. They are Principal Investigators or Project Leaders on 76 NIH grants. Apart from training grants, 29 of the mentors have NIH-funded (primarily through NCI) research grants. Over the past 10-years, the mentors have trained 210 predoctoral students and 192 postdoctoral fellows; they currently have 126 predoctoral and 111 postdoctoral trainees in their laboratories. PUBLIC HEALTH RELEVANCE: This application proposes to develop a multidisciplinary Cancer Pharmacology Training Program (CPTP) to provide predoctoral and postdoctoral trainees with a training opportunity that does not currently exist at Case Western Reserve University. The goals of the program are to teach the fundamentals of cancer pharmacology, and to train students in approaches to cancer pharmacology that involve multidisciplinary interactions. The program will thus help fill the current deficit of individuals who can move freely between disciplines and productively interact with scientists from various areas to develop the next generation of chemotherapeutic agents. These goals will be accomplished through coursework and through multidisciplinary research experiences. The program director, Noa Noy, and the advisory committee will provide the sustained leadership required for the recruitment and training of both predoctoral and postdoctoral scientists in the multidisciplinary environment of the field of cancer pharmacology. 36 faculty mentors with diverse complementary expertise will be grouped into four sub-programs: Cancer biology, Cancer Drug Design and Delivery, Imaging, and Cancer Systems biology. Each trainees will have research mentors from two of these programs.