CORE--MOUSE

核心B是转基因小鼠资源核心。这三个项目都将广泛利用 基因改造的老鼠来进行他们的实验。动物集中定位，理性 控制和分享育种种群，集中进行基因型分析，将最大限度地提高效率 并且使与所提出的实验所需的小鼠的生产相关的成本最小化。具体 核心B的活性包括（1）帮助产生另外的遗传修饰的小鼠模型， (2)（3）转基因玉米的获得及基因型分析 和/或敲除小鼠，（4）定时妊娠的产生和收集，（5）寄养、断奶和 实验动物的储存，（6）转基因小鼠模型的分发，和（7）交付 实验动物送到适当的实验室使用。核心人员已经在所有方面训练有素， 拟提供的服务。鉴于对转基因动物的严重依赖， 核心B对计划项目补助金申请成功的重要性怎么强调都不过分。

Core B is the Genetically Modified Mouse Resources Core. All three projects will make extensive use of genetically modified mice for their proposed experiments. Centralized localization of the animals, rational control and sharing of the breeding stocks, and centralization of genotype analyses will maximize efficiency and minimize costs associated with the production of the mice needed for the propose experiments. Specific activities of Core B include (1) Assistance in the generation of additional genetically modified mouse models, (2) Establishment and maintenance of breeding stocks, (3) Generation and genotype analysis of transgenic and/or knock-out mice, (4) Generation and collection of timed pregnancies, (5) Fostering, weaning and storage of the experimental animals, (6) Distribution of genetically modified mouse models, and (7) Delivery of experimental animals to the appropriate laboratory for use. Core personnel are already well-trained in all aspects of the services to be provided. Given the heavy reliance on genetically modified animals, the importance of Core B to the success of the Program Project Grant application cannot be overstated.