Administrative Core-Interdisciplinary Ctr for Male Contraceptive Res & Drug Dev

分配给U54男性避孕研究跨学科中心的空间摘要 和药物发现： 新的生物医学研究中心(BRC)将容纳所有U54研究项目首席研究员 和两个支援核心单位。堪萨斯大学医学中心将完成一座新的 耗资5200万美元的研究建筑，包含179,582净可分配平方英尺(NASF)。这座大楼的入住率 计划于2006年10月开始，2006年12月完成，将包括实验室、办公室 为所有U54研究项目首席研究员以及行政部门提供研究支持空间 和U54中心的成像核心。所有这些都将位于33,294平方英尺的3楼 (请参见下一页的图1)。这一层还将由以下两个跨学科中心占用 男性避孕研究和药物开发以及生殖科学中心，因此 为开展男性研究提供了一个高度互动、协作和支持的环境 避孕措施的发展。BRC中的各个实验室将配备齐全；没有要求 设备，因为大学已经为所有与U54相关的实验室提供了新的设备。在适当情况下， 调查人员将自己实验室的设备集中到核心，以减少重复 和成本。然而，核心(实验室和行政部门)的大部分设备是由 医学院院长办公室和之前的NIH赠款的匹配。此外，2700万美元的澳元 霍尔家庭基金会赠送给堪萨斯大学医学中心的礼物，用于购买 为移入BRC的所有调查员和岩心提供新的和更换的设备。 药物、发现、设计和合成核心(DDS Core)设在加州大学的设施中 堪萨斯-劳伦斯和明尼苏达大学。这些核心设施与目前 在我们的多校区NICHD合同中的应用非激素非类固醇男性的合成和检测 该机构位于堪萨斯大学劳伦斯分校，距离 堪萨斯大学医学中心。在目前和以前的男性避孕药具开发合同期间， 这一距离不会对两个校区之间的研究的顺利进行构成障碍。 由于OSHA的规定，药物、发现、设计和合成核心提交给调查人员的化合物 在堪萨斯大学的医疗中心必须由商业运输公司(如联邦快递连夜运输)运输。 这一程序将在U54中心以及明尼苏达大学的设施之间继续进行 以及中心的其他校区。确保良好沟通的其他行政安排 核心组件和中心的其他部分之间包括：1)基于Web的安全数据存储库 用于化学、物理和生物数据。Tash博士、Georg博士和Schonbrunn博士将在 至少每六个月(额外的旅行费用将由替代资金来源支付)，以确保 核心需求得到顺利满足。3)最后，所有涉及中心调查人员的研讨会和会议都将 在两个校区通过网络视频会议提供。 药物开发核心(DD Core)位于两所大学的设施中的行政空间 在堪萨斯医学中心和堪萨斯大学劳伦斯分校。这个核心可能是唯一的 学术中心。核心由斯科特·韦尔领导，他是药学博士，博士。威尔博士的具体专业领域是 在临床药理学方面，并在先导优化和早期药物开发方面开发创新方法。 韦尔博士在广泛的治疗领域开发了药物产品。位于的DD Core设施 KUMC位于BRC的街对面，那里是研究项目实验室和行政与成像 岩心已经找到了。

Summary of space allocated for the U54 Interdisciplinary Center for Male Contraceptive Research and Drug Discovery: New Biomedical Research Center (BRC) will house all U54 Research Project Principal Investigators and two support Core Units. The University of Kansas Medical Center will complete construction of a new $52 million research building containing 179,582 Net Assignable Square Feet (NASF). Occupancy of this building is schedule to begin in October, 2006 and be completed by December, 2006 and will include laboratory, office, and research support space for all of the U54 Research Project Principal Investigators as well as the Administrative and Imaging Cores of the U54 Center. These will all be located on the 33,294 square foot 3rd floor of the BRC (see Figure 1, next page). This floor will also be occupied by both the Interdisciplinary Center for Male Contraceptive Research and Drug Development and the Center for Reproductive Sciences, and thus represents a highly interactive, collaborative, and supportive environment for conducting the research on male contraceptive development. The individual labs in the BRC will be well equipped; there are no requests for equipment since the university has provided new equipment for all labs associated with this U54. Where appropriate, investigators have centralized equipment from their own labs into the core in order to reduce duplication and costs. However, most of the equipment in the cores (laboratories and administrative) was provided by the Dean's office of the School of Medicine and by matching of previous NIH grants. In addition, a $27 million gift from the Hall Family Foundation to the University of Kansas Medical Center provided for the purchase of new and replacement equipment for all of the investigators and cores moving into the BRC. The Drug, Discovery, Design & Synthesis Core (DDS Core) is housed in facilities at the University of Kansas-Lawrence and at the University of Minnesota. These are the same core facilities that are currently being utilized in our multi-campus NICHD contract "Synthesis and Testing of Non-hormonal Non-Steroidal Male Contraceptive Agents." The location of the facility at University of Kansas-Lawrence is about 30 miles from the University of Kansas Medical Center. During the current and previous contract on male contraceptive development, this distance provides no barrier to the smooth conduct of the research between the two campuses. Due to OSHA regulations, compounds submitted by the Drug, Discovery, Design & Synthesis core to investigators at University of Kansas Medical Center must be transported by commercial carriers (such as FEDEX overnight). This procedure will continue in the U54 center, as well as between the facilities at the University of Minnesota and the other campuses in the Center. Other administrative arrangements to ensure good communications between the core components and the rest of the center include: 1) A secure web-based data repository for chemical, physical, and biological data. 2) Drs. Tash, Georg, and Schonbrunn will be meet face-to-face at least every six months (additional travel costs will be covered by alternate funding sources) to make sure the core needs are being met smoothly. 3) Finally, all seminars and meetings involving center investigators will be available by web video conference at both campuses. The Drug Development Core (DD Core) is located in administrative space in facilities at both the University of Kansas Medical Center and at the University of Kansas-Lawrence. This core is probably unique in an academic center. The core is headed by Scott Weir, Pharm.D, Ph.D.. Dr. Weir's specific areas of expertise are in clinical pharmacology and developing innovative approaches in lead optimization and early drug development. Dr. Weir has developed drug products across a wide range of therapeutic areas. The DD Core facility at KUMC is located across the street from the BRC, where the research project labs and Administrative and Imaging cores are located.