Hormonal modulation of lung Na transport

排列在肺内表面的细胞具有分子泵和通道，它们一起提供了驱动流体移动穿过肺壁的机制。它们的正常功能在出生前、出生时和出生后至关重要。因此，在出生前，液体分泌到肺中产生了一个液体模板，在其周围发育的气隙生长。在出生时，如果新生儿要正常呼吸，这种液体必须被吸收。然而，从出生到童年到成年，肺的内部虽然充满了空气，但却衬有一层薄薄的液体-其体积和成分由肾上腺素非常精确地调节（快速作用？逃跑还是战斗激素）、长效激素如甲状腺激素和类固醇激素。扰乱这些调节机制是许多严重肺部疾病的基础，包括新生儿呼吸窘迫、肺水肿（如高原反应）和囊性纤维化。本申请中描述的工作将定义控制流体吸收中涉及的分子通道的方式，以保持肺干燥，从而允许维持肺功能。

The cells which line the interior surface of the lung possess molecular pumps and channels which together provide a mechanism for driving fluid movement across the walls of the lung. Their normal functioning is crucial before, during and after birth. Thus, before birth, the secretion of fluid into the lung generates a liquid template around which the developing airspaces grow. At birth, this fluid must be absorbed if the newborn baby is to breathe normally. However, from birth through childhood into adult life, the interior of the lung, although air-filled, is lined by a thin film of liquid - the volume and composition of which is very precisely regulated by adrenaline (the rapid acting ?flight or fight? hormone), long acting hormones such as thyroid and steroid hormones. Disrupting these regulating mechanisms underlies a number of serious lung disorders, including respiratory distress of the newborn, pulmonary oedema (e.g. altitude sickness) and cystic fibrosis. The work described in this application will define the ways in which the molecular channels involved in fluid absorption are controlled in order to keep the lungs dry and thus allow lung function to be maintained.