Training Program in Clinical & Translationa Research in Human Glomerular Disease

培训计划：NSRDCRN临床和转化研究培训计划， 人类肾小球疾病 1.介绍 1.1.目的：NSRDCRN培训计划是专为高级博士后和初级教师 受训人员，或有意改变调查重点的资深调查人员， 成为人类肾小球疾病临床和转化研究的独立研究者。 培训将为每个受训者量身定制，将教学计划与指导计划相结合， 利用肾病综合征罕见疾病联盟资源的研究经验。 1.2.依据：如本NSRDCRN申请的其他部分所述，人体临床研究 肾小球疾病在过去几十年中进展缓慢， 不充分的信息，以正确地指导他们的病人的护理。缺乏调查基础设施 资金不足阻碍了现代遗传学的发展， 分子生物学和系统生物学工具。这些相同的工具推动了一些领域的进步， 以多种罕见疾病为主的肿瘤学。如果没有协作基础设施， 已经出现了成熟的研究者来进行肾小球疾病的研究。此外，由于机会不多，很少有潜在的调查人员被吸引到这一研究领域，目前很少有人接受培训，以推动这一领域的发展。第一个研究罕见肾小球疾病的北美合作网络的建立提供了机会和宝贵的资源，将被利用来扩大采用现代实验方法在这一领域工作的科学家队伍。为了满足这一需求，NSRDCRN将创建一个计划，为有兴趣研究肾小球疾病的有才华的学员提供财政支持，强大的指导研究环境，以及获得NS罕见病联盟收集的独特资源，临床数据或标本。

Training Program: The NSRDCRN Training Program in Clinical and Translational Research in Human Glomerular Disease 1. Introduction 1.1. Objectives: The NSRDCRN training program is designed for advanced post-doctoral and junior faculty trainees, or established investigators interested in redirecting their investigative focus, who are preparing to become independent investigators in clinical and translational research in human glomerular disease. Training will be individually tailored for each trainee, combining a didactic program with a mentored research experience that employs the resources of the Nephrotic Syndrome Rare Disease Consortium. 1.2. Rationale: As detailed elsewhere in this NSRDCRN application, clinical investigation of human glomerular disease has progressed slowly over the past several decades leaving renal practitioners with inadequate information to properly direct their patient's care. The absence of an investigative infrastructure and insufficient funding have impeded the advances that are now possible using modern genetics, molecular biology, and systems biology tools. These same tools have propelled advances in fields such as oncology where multiple rare diseases predominate. Without a collaborative infrastructure, relatively few established investigators have emerged to conduct glomerular disease investigations. Moreover, given poor opportunity, few potential investigators have been drawn to this area of study and few are presently training to carry this field forward. The creation of the first North American collaborative network to study rare glomerular diseases provides opportunity and a valuable resource that will be exploited to expand the pool of scientists who employ modern experimental approaches for work in this field. To address this need, the NSRDCRN will create a program that provides talented trainees interested in studying glomerular disease with financial support, a strong mentoring research environment, and access to the unique resources, clinical data, or specimens assembled by the NS Rare Disease Consortium.