Genetics of Polygenic Obesity

在英国，肥胖(以体重指数30公斤/平方米定义)正接近流行病的比例，据估计，仅在几年内就有三分之一的人口受到影响。肥胖容易导致2型糖尿病、冠状动脉疾病、骨关节炎和一些癌症，导致预期寿命显著缩短，特别是在年轻的肥胖者中。儿童肥胖症现在影响着5-10岁年龄组中20%-30%的儿童。虽然营养不良和久坐不动的生活方式是最近这场流行病的主要原因，但严重和早发性肥胖都有很强的遗传基础，并且是生活在肥胖人群中的个体DNA变异累积效应的结果。环境。换句话说，遗传易感性的儿童是我们有害生活方式的第一个也是最受影响的受害者。识别肥胖和相关的糖尿病基因以及风险双标记物将为预防和治疗这种疾病提供重要信息，从而显著提高英国人口的生活质量和生产力。

In the UK obesity (defined by a Body Mass Index 30kg/m2) is nearing epidemic proportions, with estimates of 1/3 of the population being affected within only a few years. Obesity predisposes to type 2 diabetes, coronary artery disease, osteoarthritis and some cancers leading to a significant reduction in life expectancy, especially in the young obese. Childhood obesity now affects 20-30% of children in the 5-10 years old age group. Although bad nutrition and sedentary lifestyle play a major role in this recent epidemics, severe and early onset forms of obesity both have a strong genetic basis and result from the cumulative effects of DNA variation in individuals living within an ?obesogenic? environment. In other words, genetically predisposed children are the first and most affected victims of our deleterious way of life. Identifying obesity and associated diabetes genes and risk bimarkers will provide vital information for the prevention and treatment of the condition, resulting in significant improvements in the quality of life and productivity in the UK population.