La Jolla Interdisciplinary Neuroscience Center Cores - Bioinfo core Salk

生物信息学和系统生物学/数据管理核心 1.主要举措和新方向 生物信息学和系统生物学/数据管理核心是现有的核心， BIMR癌症中心。类似的核心存在于索尔克研究所和UCSD。在所有三种情况下 神经科学家对这些核心的接触有限或根本没有，只能依靠非正式的个人联系。 生物信息学和数据管理支持。NIH神经科学蓝图核心中心 格兰特将使这些设施提供给拉霍亚托里松树梅萨的神经科学家。的 核心将总部设在BIMR与卫星设施，电子连接，在索尔克和 UCSD超级计算机设施。主任博士亚当Godzik位于BIMR和联合主任格哈德 索尔克研究所的曼宁（Godzik和曼宁都是UCSD超级计算机的成员） 设施，因此也可以在UCSD访问）。这个核心的使命有三个方面。一是 该设施将为一套100多个公开的信息学项目提供支持和培训 可以被神经科学家使用。第二，该设施将创造一个虚拟环境， 存档、分析和共享在各个实验室研究的特定蛋白质的数据 这是NIH神经科学蓝图中心核心资助的一部分。类似于“癌症分子” 由伯纳姆癌症中心开发的“神经科学分子”数据库 页面数据库”将显示单个蛋白质的许多重要方面（序列和结构 信息，参与生物化学途径，并链接到发表在蛋白质上的关键论文） 与神经系统疾病有关第三，也是最重要的是，该基金将产生综合的 用于存档、分析和传播其他四个国家所产生的信息的工具 神经科学中心核心设施：高通量细胞分析设备，基因分析 设施，蛋白质组学设施和化学文库筛选设施。每一个设施 将产生大量的数据。信息学设施的作用是建立 收集和分析数据的自动化方法;以及生成查询协议（自动化 在可能的情况下）用于探测数据集以识别重要特征。的意图是 创建一个关系数据库的工具，调查人员可以在其中同时查询 来自所有四个机构的数据，各个实验室存档的数据，以及 公共领域（PubMed，USPTO，PDB等）。

BIOINFORMATICS AND SYSTEMS BIOLOGY/DATA MANAGEMENT CORE 1. MAIN OBJECTIVES AND NEW DIRECTIONS The Bioinformatics and Systems Biology/Data Management Core is an existing Core in the Cancer Center at BIMR. Similar cores exist at The Salk Institute and UCSD. In all three cases neuroscientists have limited or no access to these cores and have to rely of informal, personal links for bioinformatics and data management support. This NIH Neuroscience Blueprint Core Center Grant will make these facilities available to Neuroscientists on the La Jolla Torrey Pines Mesa. The Core will be headquartered at BIMR with satellite facilities, linked electronically, at The Salk and the UCSD Supercomputer facility. Director Dr. Adam Godzik is located at BIMR and Co-Director Gerhard Manning at The Salk Institute (both Godzik and Manning are members of the UCSD Supercomputer Facility and thus have access at UCSD as well). The mission of this Core is three-fold. First, the Facility will provide support and training for a set of over 100 publicly available informatics programs that can be used by neuroscientists. Second, the Facility will create a virtual environment for archiving, analyzing, and sharing data on specific proteins that are studied in individual laboratories that are part of this NIH Neuroscience Blueprint Center Core Grant. Similar to the "Cancer Molecule Pages Database" being developed by the Burnham Cancer Center, the "Neuroscience Molecule Pages database" will display many important aspects of individual proteins (sequence and structural information, involvement in biochemical pathways, and links to key papers published on the protein) involved in neurological diseases. Third, and most significantly, the Facility will generate integrated tools for archiving, analyzing, and disseminating information generated in four of the other Neuroscience Center Core Facilities: High Throughput Cell Analysis Facility, the Gene Analysis Facility, the Proteomics Facility and the Chemical Library Screening Facility. Each of these Facilities will generate massive volumes of data. The role of the Informatics Facility will be to establish automated methods of collecting and analyzing the data; and to generate query protocols (automated where possible) for probing the data sets to identify features of significance. It is the intent of the Facility to create a relational database where investigators can make simultaneous queries across data from all four Facilities, across data archived from individual laboratories, and information in the public domain (PubMed, USPTO, PDB etc.).