SYNTHETIC CHEMISTRY: MASS SPECTROMETRY FOR COMPOUND IDENTIFICATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该集团对合成有机、无机和有机金属化学、过渡金属催化的不对称反应合成生物活性化合物、仿生化学、分子识别和材料化学感兴趣。在过去的几年里，他们加快了开发创新的手性配体和新反应的努力。虽然他们已经发明了三个手性配体(PennPhos，BICPs和Ambox)，但张组开发了14个新的配体(例如，Binaphane，ketalPhos，P，N配体，TunaPhos，Diop*，FAP和TangPhos)。这些有效的配体进一步拓宽了许多不对称反应的范围，并将有许多实际应用。 开发新型过渡金属催化反应是有机合成中的重要任务。张组正在评估Rh催化的烯炔异构化反应，在温和的条件下仅提供1，4-二烯，并实现了第一个高对映选择性的烯反应。 在金属催化环化方面，张组发明了第一个高对映选择性的银催化的[3+2]环加成反应，用于合成五元环含氮杂环化合物。这些杂环化合物可以很容易地从现成的醛、氨基酯和偶极化合物中制备出来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Zhang group is interested in synthetic organic, inorganic and organometallic chemistry, transition metal catalyzed asymmetric reactions for the synthesis of biologically active compounds, biomimetic chemistry, molecular recognition and material chemistry. During the last few years, they accelerated effort in developing innovative chiral ligands and new reactions. While they already invented three chiral ligands (PennPhos, BICP and Ambox), the Zhang group developed fourteen new ligands (e. g., Binaphane, ketalPhos, P, N ligands, TunaPhos, DIOP*, FAP and TangPhos). These effective ligands further broaden the scope of many asymmetric reactions and will have many practical applications. Developing new transition metal-catalyzed reactions are important missions in organic synthesis. The Zhang group is evaluating Rh-catalyzed enyne isomerization to offer 1,4-dienes exclusively under a mild condition and the first highly enantioselective ene reaction was achieved. In the area of metal-catalyzed cyclization, the Zhang group has invented the first highly enantioselective Ag-catalyzed [3+2] cycloaddition for the synthesis of five-membered ring N-containing hetereocyclics. These hetereocyclics can be easily prepared from ready available aldehydes, aminoesters and dipolarphiles.