Pre-doctoral Research Training in Human Genetic Epidemiology

描述(申请人提供)：超出所提供的空间。根据美国国立卫生研究院PA-02-109号文件提交的这份重新修订的博士前培训补助金申请，要求以一种非常成功和有效的实践方法，将生物统计学和计算科学(遗传流行病学、生物统计学、统计遗传学和生物信息学)与生物科学(人类遗传学、分子生物学和基因组学)相结合，支持在“跨文化”跨学科环境中培训未来的遗传流行病学家。我们相对较新的“数量人类和统计遗传学”博士前课程融合了传统和非传统方法。该计划的主要目标是：(1)培训遗传流行病学家和统计遗传学家分子方法和分子数据分析技术，以及(2)培训人类遗传学家统计遗传学途径和方法，使他们能够熟练地分析他们产生的数据。我们相信，这一博士前项目将有效地将文化冲击降至最低，这种文化冲击往往会阻碍遗传流行病学家充分参与跨学科研究。这笔培训补助金的资金将支持这一新开发的计划，该计划将针对本科专业为统计科学或生物科学的研究生，并对其他专业具有一定程度的熟练程度。我们要求为第一年的4个位置和之后的6个位置提供资金。我们的建议是通过将精心挑选的教学培训与华盛顿大学非常成功的直接动手学习模式进行更多的强调来应对挑战。这一培训计划的一大优势在于，整个DBBS以及另一个硕士学位培训计划(GEMS)的庞大现有资源和丰富的跨学科培训环境也适用于该计划的所有博士前学生。我们希望，通过让我们的学生接触到成熟的DBBS课程和资源的全部广度和深度，我们正在确保我们的学生将以非常自然的方式与生物医学科学充分融合，从而确保有效的“跨文化”培训。我们相信，我们的培训计划非常符合PA的精神，渴望培养出未来的遗传流行病学家，在当前市场对合作生物医学研究的需求很大。

Description (provided by applicant): EXCEED THE SPACE PROVIDED. This re-revised pre-doctoral training grant application, submitted in response to NIH PA-02-109, requests support to train future Genetic Epidemiologists in a "cross-culture" interdisciplinary environment by integrating biostatistical and computational sciences (genetic epidemiology, biostatistics, statistical genetics, and bioinformatics) with biological sciences (human genetics, molecular biology, and genomics) using a highly successful and effective hands-on approach. Our relatively new pre-doctoral program in "Quantitative Human and Statistical Genetics" blends traditional and non-traditional approaches. The primary objectives of this program are: (1) To train Genetic Epidemiologists and Statistical Geneticists in molecular methods and molecular data analysis techniques, and (2) To train Human Geneticists in statistical genetics approaches and methods so that they can analyze competently the data they generate. We believe that this pre-doctoral program will effectively minimize the culture shock that often inhibits genetic epidemiologists from participating fully in interdisciplinary research. Funding of this training grant will support this newly developed program which will target graduate students whose undergraduate major was in either statistical sciences or biological sciences with some degree of proficiency in the other. We are requesting funds for 4 slots in the first year and 6 thereafter. Our proposal rises to the challenge by blending and integrating carefully chosen didactic training with greater emphasis on a direct hands-on learning format found to be immensely successful at Washington University. One of the great strengths of this training program is that the vast established resources and rich interdisciplinary training environment of the entire DBBS, as well as that of another masters degree training program (GEMS), are also available to all pre-doctoral students in this program. It is our hope that, by exposing our students to the full breadth and depth of the mature DBBS programs and resources, we are ensuring that our students will be fully integrated with the biomedical sciences in a very natural manner thus also ensuring effective "cross-culture" training. We believe that our training program is very much in the spirit of the PA, aspiring to produce future genetic epidemiologists in much demand in the current market place for pursuing collaborative biomedical research.