A generic approach to disrupting protein-protein interactions application to the hIgE-FceRI interface

哮喘和其他过敏症状是由血液中一种叫做IgE的蛋白质检测过敏原（来自花粉、尘螨等）在分子水平上引发的复杂级联事件的结果，最终导致有毒炎症因子的释放（导致气道炎症等）。本研究旨在合理开发能够阻止某些细胞表面IgE与其受体蛋白对接的分子，从而防止过敏原激活后有害炎症因子的产生。被确定为有效阻断这一关键蛋白-蛋白结合事件的分子有望为抗过敏药物的开发提供令人兴奋的线索。此外，由于相关的蛋白质-蛋白质结合事件在人类疾病过程中广泛存在，因此对这些相互作用被破坏的方式的理解水平的提高可能在许多医学和保健领域具有重要的治疗价值。

Asthma and other allergic manifestations are the result of a complex cascade of events at the molecular level initiated by the detection of an allergen (from pollen, dust mites etc.) by a protein in the blood called IgE, which culminates in the release of toxic inflammatory agents (resulting in airway inflamation etc.). This research is aimed at the rational development of molecules that are able to prevent the docking of IgE to its receptor protein on the surface of certain cells, thereby preventing the generation of the harmful inflammatory agents following activation by allergens. The molecules identified as being effective for blocking this key protein-protein binding event are expected to constitute exciting leads for the development of anti-allergic drugs. Moreover, since related protein-protein binding events are widespread in human disease processes, an increased level of understanding of the manner in which these interactions can be disrupted is likely to be of significant therapeutic value in many areas of medicine and healthcare.