Primate Studies

灵长类研究核心促进辐射缓释剂晚期临床前研究的进行 非人类灵长类动物的损害，遵循RadCCORE联盟和其他CMCR的特定优先事项 全国范围内，包括自2007年以来在其他地方对在高剂量辐射中存活的动物进行长期护理和研究 机构。因为非人灵长类动物在遗传和生理上与人类高度相似 此资源是候选可交付代理的翻译评估的关键组件，在 可给予健康受试者相应剂量的全身照射的实验设置。 核心研究人员在非人类灵长类动物的实验使用和临床医学方面拥有独特的技能， 包括辐射、兽医护理和骨髓抑制动物的管理，比较 灵长类动物病理学、辐射损伤病理学、生化、临床病理学和内分泌学 灵长类动物，以及使分子生物学技术适应灵长类动物模型。核心服务包括 获得和维持无特定病原体的非人类灵长类动物，使动物暴露在辐射中， 实施治疗干预措施，并对治疗结果进行临床和病理评估， 包括尸检/组织收集和共享，以确定辐射反应和 对减轻干预措施的评估。核心还为灵长类提供广泛的数据管理服务 研究，包括数据和组织共享。

The Primate Stutiies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates, following the specific priorities of the RadCCORE consortium and other CMCRs nationwide, including since 2007 long-term care and study of animals surviving high-dose irradiation at other institutions. Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational assessment of candidate deliverable agents, in an experimental setting under which relevant doses of whole-body irradiation can be given to healthy subjects. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates, including irradiation, veterinary medical care and management of myelosuppressed animals, comparative pathology of primates, pathology of radiation injury, biochemistry, clinical pathology and endocrinology of primates, and adaptation of molecular biologic techniques to the primate model. Core services include acquisition and maintenance of specific-pathogen-free nonhuman primates, exposure of animals to radiation, administration of therapeutic interventions, and clinical and pathologic assessments of treatment outcomes, including necropsy/tissue collection and sharing for baseline characterization of radiation responses and assessment of mitigating interventions. The Core also provides extensive data management services for primate studies, including data and tissue sharing.