Amblyopia in Astigmatic Children - Development & Treatment

描述（由申请人提供）：未矫正视力模糊者的视觉体验提供了一个关于慢性模糊对视觉发育影响的独特自然实验。对Tohono O 'odham儿童的研究，其中30 - 40%的儿童有明显的视力散光，为研究散光的影响提供了一个独特的机会。拟议研究的第一个目的是确定与Tohono O 'odham儿童眼镜佩戴依从性相关的因素，这将为未来制定提高治疗依从性的策略提供重要信息。第二个目的是确定未矫正散光对复杂和日常视觉任务（形式和运动的整体感知、视觉运动整合、阅读）的未矫正和矫正性能的影响，并将提供散光如何影响日常功能以及当儿童佩戴最佳矫正时是否影响执行这些任务的能力的发展的见解。第三个目的是研究未矫正的视力障碍儿童的视觉体验之间的关系，考虑到特定任务的矫正模式，以及最佳矫正的视觉缺陷的具体模式，结果。这些数据将使我们更好地理解视觉体验和视觉发育之间的复杂关系。目的2和3还将提供关于显著破坏视觉性能所需的未矫正散光量以及破坏执行简单、复杂和日常视觉任务所需的视觉能力的正常发育所需的散光量的有价值的临床信息。最终目的是研究Tohono O 'odham儿童散光随时间的稳定性，并确定其散光的解剖学起源。这项研究将检查2,000多名学龄儿童散光的长期变化。此外，后角膜的测量将提供关于内部散光的起源的基本数据，内部散光通常补偿外部（前）角膜散光。相关性（见说明）：这项研究将产生重要的临床信息，以帮助制定治疗和预防弱视相关性弱视的指南，将进一步加深我们对视觉经验对视觉发育影响的基本理解，并将首次分析该人群中内部散光的解剖起源。

DESCRIPTION (provided by applicant): The visual experience of the uncorrected astigmat provides a unique natural experiment on the effect of chronic blur on visual development. Studies of Tohono O'odham children, 30 to 40% of whom have visually significant astigmatism, provide a unique opportunity for investigation of the effects of astigmatism. The first aim of the proposed research is to determine factors associated with spectacle wearing compliance in Tohono O'odham children, which will provide essential information for the development of future strategies to increase treatment compliance. The second aim is to determine the effect of uncorrected astigmatism on both uncorrected and corrected performance of complex and everyday visual tasks (global perception of form and motion, visual motor integration, reading), and will provide insight into how astigmatism impacts everyday functioning and whether it affects the development of the ability to perform these tasks when the child is wearing best correction. The third aim is to examine the relation between the visual experience of uncorrected astigmatic children, taking into account task-specific accommodative patterns, and the specific patterns of best-corrected visual deficits that result. These data will allow us to better understand the complex relation between visual experience and visual development. Aims 2 and 3 will also provide valuable clinical information regarding the amount of uncorrected astigmatism necessary to significantly disrupt visual performance and the amount of astigmatism necessary to disrupt normal development of visual capabilities necessary to perform simple, complex, and everyday visual tasks. The final aim is to study the stability of astigmatism in Tohono O'odham children over time, and to determine the anatomical origins of their astigmatism. The research will examine long-term change in astigmatism in over 2,000 school-age children. In addition, measurements of the posterior cornea will provide fundamental data on the origin of the internal astigmatism that often compensates for external (anterior) corneal astigmatism. RELEVANCE (See Instructions): This research will will generate important clinical information to aid in the development of guidelines for treatment and prevention of astigmatism-related amblyopia, will further our basic understanding of the influence of visual experience on visual development, and will provide the first analysis of the anatomic origins of internal astigmatism in this population.