Biomechanics of the False Vocal Folds

描述(由申请人提供)：这项研究的长期目标是建立脑室或假声带(FVF)存在所涉及的功能性嗓音障碍的生物力学、声学和空气动力学相关性。这一目标必然包括开发和使用有效的发声模型，以及量化控制喉部功能和嗓音质量的生物力学、空气动力学和声学因素。这项应用的目的是建立对假声带振荡的生物力学、空气动力学和声学的确切理解。这一目标将通过实验和计算相结合的方法来实现。这个项目有四个具体目标。这些目标是：1)确定不规则的FVF振荡的有害影响，2)确定FVF组织的生物力学和组织学特征，3)确定与FVF定位相关的空气动力学和声学效应，以及4)量化FVF对喉部振荡的生物力学影响。这项建议具有很强的临床意义，因为它解决了一些主要关注的声音障碍，如室性晕厥。这个项目的成功完成将加强我们对脑室声带的形态和功能的了解，包括它们对正常声音产生的影响以及它们对声音改变或紊乱的贡献。对FVF解剖学、生物力学和神经肌肉控制的详细和系统的研究有望为声音产生及其控制的机制提供重要的见解，并改进我们治疗病理性声音的方法。在这个提案中，我们打算回答关于以下方面的研究问题：振动特性(Fo范围、运动幅度、运动对称性、模式)、声学特性(依赖于内收、延长、A-P压缩)、空气动力学(压力、流量、流动阻力、PTP)和组织特性(弹性模数、粘度、肌肉结构)。 公共卫生相关性：该项目调查了与某些嗓音障碍相关的脑室声带及其功能行为的生物力学。这是一个实验和计算项目，测量心室折叠的组织结构和生物力学特性，并量化正常和异常的心室折叠振荡产生的气流和声音。

DESCRIPTION (provided by applicant): The long-range objective of this research is to establish biomechanical, acoustic, and aerodynamic correlates of functional voice disorders that are implicated by the presence of the ventricular or false vocal folds (FVF). This goal, by necessity, must include the development and use of effective models of phonation, and quantification of the biomechanical, aerodynamic, and acoustic factors that control laryngeal function and voice quality. The objective of this application is to establish a firm understanding of the biomechanics, aerodynamics, and acoustics of false vocal fold oscillation. This objective will be met through a combination of experimental and computational methods. There are four specific aims in this project. These aims are: 1) To establish the detrimental effects of irregular FVF oscillations, 2) To identify the biomechanical and histological characteristics of FVF tissue, 3) To identify the aerodynamic and acoustic effects associated with FVF positioning, and 4) To quantify the biomechanical effects of the FVF on laryngeal oscillations. This proposal has strong clinical relevance as it addresses some of the major concerns in voice disorders such as ventricular disphonia. The successful completion of this project will enhance our understanding of the form and function of the ventricular vocal folds, both with respect to their influence in normal sound production and their contribution to altered or disordered voice. Detailed and systematic study of FVF anatomy, biomechanics, and neuromuscular control can be expected to provide important insights into the mechanism of sound production and its control, and improvements in our approaches to treating the pathological voice. In this proposal we intend to answer research questions regarding: vibratory characteristics (Fo range, amplitude of motion, symmetry of motion, modes), acoustic characteristics (dependence on adduction, lengthening, A-P compression), aerodynamics (pressure, flow, flow resistance, PTP), and tissue characteristics (elastic modulus, viscosity, muscle architecture). PUBLIC HEALTH RELEVANCE: This project investigates the biomechanics of the ventricular vocal folds and their functional behavior that associated with some voice disorders. It is an experimental and computational project that measures ventricular fold tissue structure and biomechanical properties and quantifies airflow and sound generation from normal and abnormal ventricular fold oscillations.