Clinical Observations of Ocular Lens Ultrastructural Changes with Age and Accommo

描述（由申请人提供）：调节是镜头的主要功能。在动态聚焦过程中，透镜的形状会发生变化。随着年龄的增长，晶状体的调节能力会逐渐下降，到40岁左右就会成为一个明显的问题。提出纤维细胞独特的结构特征和组织使它们能够在缝合线处相互连接。这种界面导致在透镜的表面曲率的变化，以及厚度的增加，允许近焦点发生。通过对人死后晶状体间和晶状体内的分析，这些变化的特征为不同年龄的调节范围差异提供了解释。在老化和适应过程中，透镜经历了使用波前分析测量的特征变化。然而，高阶像差外观的细微变化与透镜的超微结构之间的联系尚未被研究。使用裂隙灯和光线追踪像差法，我们计划了解住宿期间缝合线的正常变化，以及不同年龄的缝合线。裂隙灯缝合外观和畸变模式的正常数据库将用于为适应性功能障碍提供客观测量，特别是在不能有效报告其问题的年幼儿童中。

DESCRIPTION (provided by applicant): Accommodation is a main function of the lens. During dynamic focusing, the shape of the lens is changed. The accommodative ability of the lens decreases throughout life, such that it becomes a noticeable problem by around the age of 40. It is proposed that unique structural features and organization of fiber cells enables them to interface at the sutures. This interfacing results in a change in surface curvature of the lens, as well as an increase in thickness, allowing near focus to occur. Using inter- and intra-lens analysis of post- mortem human lenses, the characterization of these changes has provided an explanation for the differences in accommodative range seen across age. During both aging and accommodation, the lens undergoes characteristic changes that have been measured using wavefront analysis. However, the connection between the subtle changes in appearance of the higher order aberrations and ultrastructure of the lens has not been investigated. Using slit lamp and ray-tracing aberrometry, we plan to create an understanding of normal changes in sutures during accommodation, as well as across age. A normal database of slit lamp suture appearance and aberration patterns will then be used to provide an objective measure for accommodative dysfunction, particularly in younger children, that are not able to report their problems effectively. PUBLIC HEALTH RELEVANCE: Changes occur in the lens shape and structure with age. We propose to improve methods to detect these changes. We want to provide clinicians with better tools to detect and understand how these changes can affect our ability to focus on a near object throughout life.