Low-cost High-resolution fundus camera

摘要摘要 主要目标是在临床上展示一种商业上可行的、低成本、高分辨率的眼底照相机： 易于使用，即与当前眼底相机的操作一致；具有典型的视场(FOV) 目前的眼底相机(15到30度)；与现有的相比，分辨率提高了五倍或更多 临床设备；而且，价格将低于今天的临床设备。在第一阶段，一种低成本的删除方法 显示了低阶像差，焦点和散光。结果表明，低阶像差的去除 将产生明显更好的分辨率图像。在第二阶段，具体目标是整合低成本的低阶 在扫描激光检眼镜(SLO)中安装像差补偿器。这种新的SLO将产生视网膜和视盘 与今天的商用相机相比，分辨率提高了五倍的图像。 研究人员试图在高空向下更深入地了解视网膜和视盘的机制 能够显示毛细血管和神经纤维等结构(4至8微米)的分辨率 捆绑在一起。视网膜图像质量下降的主要来源是人眼内的像差。这些东西的存在 眼睛的像差，其中许多是随机的和不确定的，限制了可实现的分辨率和小的对比度 由于绕射效应而产生的图像细节。为了克服这些基本限制，研究人员一直在应用 采用自适应光学技术来校正像差。今天，基于变形镜的自适应光学设备具有 是为了克服标准眼底相机的局限性而开发的，但价格超过50万美元。 VisionQuest提出的设备解决了与上述研究级自适应光学仪器相同的目标，但 这种方法最终将更适合临床使用，因为它与目前的视网膜相似 摄影技术及其低成本技术。我们建议的设备避免了高昂的成本、复杂性和 通过采用独特且明显更便宜的波前测量和像差校正技术来限制视场。 VisionQuest的目标是展示一种先进的成像技术，它引入了一种有效和低成本(1万美元)的 或更少)医疗保健系统的诊断工具。叙事 用于诊断视网膜疾病或监测治疗和/或进展的视网膜成像 视网膜疾病是护理的标准。极大地改善了视网膜的图像，特别是以低于当前成本的成本 眼底相机，将对我们在全美实施大规模筛查的能力产生重大影响。 治疗视网膜疾病。低成本的视网膜摄像头将使任何患有以下疾病的人能够及早发现和护理 三种主要眼病，即老年性黄斑变性、糖尿病视网膜病变或青光眼。

SUMMARY  ABSTRACT The principal objective is to demonstrate clinically a commercially viable, low-cost, high-resolution fundus camera that: is easy to use, i.e., consistent with the operation of current fundus cameras; has a field of view (FOV) that is typical of current fundus cameras (15 to 30 degrees); has a factor of five or more improvement in resolution as compared to existing clinical instruments; and, will be priced below that of today's clinical devices. In Phase I, a low-cost means for removing low-order aberrations, focus and astigmatism, was demonstrated. It was shown that removal of low-order aberrations would result in significantly better resolution images. In Phase II, the specific aims are to integrate the low-cost low-order aberrations compensator into a scanning laser ophthalmoscope (SLO). This new SLO would produce retinal and optic disc images that have five times better resolution when compared to today's commercial cameras. Researchers have sought to gain greater insight into the mechanisms of the retina and the optic disc at high spatial resolutions that would enable the visualization of structures (4 to 8 micrometers) such as capillaries and nerve fiber bundles. Major sources of retinal image quality degradation are aberrations within the human eye. The presence of these ocular aberrations, many of them random and non deterministic, limits the achievable resolution and the contrast of small image details due to diffraction effects. To overcome these fundamental limitations, researchers have been applying adaptive optics techniques to correct for the aberrations. Today, deformable mirror based adaptive optics devices have been developed to overcome the limitations of standard fundus cameras, but at prices in excess of $500,000. The device proposed by VisionQuest addresses the same goals as the above research grade adaptive optics instruments but does so in a manner which will ultimately be better suited for clinical use because of its similarity to current retinal photographic techniques and its lower cost technology. Our proposed device avoids the high costs, complexity, and limited FOV by adopting unique and notably less expensive wavefront measurement and aberration correction techniques. VisionQuest's goal is to demonstrate an advanced imaging technology that introduces an effective and low cost ($10,000 or less) diagnostic tool to the healthcare system. NARRATIVE Retinal imaging for the purposes of diagnosis of retinal diseases or for monitoring the treatment and/or progression of retinal diseases is standard of care. Greatly improved images of the retina, especially at costs that are lower than current fundus cameras, would have a significant impact on our ability to implement broad-scale screening throughout the U.S. for retinal disease. A low-cost retinal camera would enable the early detection and care of individuals with any of the three major eye diseases, i.e., age-related macular degeneration, diabetic retinopathy, or glaucoma.