COBRE: WVU: SIGNAL TRANSDUCTION & CANCER: ADMINISTRATIVE CORE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 癌症不成比例地影响西弗吉尼亚州和阿巴拉契亚的公民，宫颈癌、肺癌、头颈癌、卵巢癌和乳腺癌的健康差异就是明证。西弗吉尼亚大学成立了玛丽巴布兰多夫癌症中心（MBRCC）来解决这个问题。 为了实现这一目标，我们将建立一个符合NCI指定为临床癌症中心的标准的癌症中心。 在第一阶段，我们的CobRE资助MBRCC协调癌症中心的成员和项目的组织，为试点项目，核心设施和实验室/办公空间提供匹配的支持，为新的教师招聘。 此外，COBRE还为五个初级教师研究项目、核心设施基础设施和教师招聘配套资金提供了支持。 我们成功招募了8名教师，指导5名初级教师获得独立研究项目资助（RPG）资金，建立了两个新的核心设施，并扩大了第三个核心设施的范围。 在第二阶段，我们试图增加我们的基础科学研究计划的深度，长期目标是将基础研究项目与转化研究计划相结合。 在未来一年，我们的具体目标包括（a）继续我们的管理核心，（B）支持在流式细胞术，生物信息学，成像和蛋白质纯化的核心设施和（c）支持五个初级教师的研究项目，并指导这些教师的独立性。该Cobre计划将促进我们实现NCI指定为临床癌症中心的长期目标，为西弗吉尼亚州和周边阿巴拉契亚地区的患者群体提供服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer disproportionately affects the citizens of West Virginia and Appalachia, as evidenced by health disparities in cervical, lung, head & neck, ovarian and breast cancers. The Mary Babb Randolph Cancer Center (MBRCC) was established at West Virginia University to address this problem. Toward that goal we will establish a cancer center that meets the criteria for NCI designation as a Clinical Cancer Center. In Phase I of our CoBRE funding the MBRCC coordinated cancer center membership and organization of programs, provided matching support for pilot projects, core facilities and lab/office space for new faculty hires. In addition, the CoBRE provided support for five junior faculty research projects, core facility infrastructure and matching funds for faculty recruitment. We successfully recruited 8 faculty members, mentoring 5 junior faculty to independent research project grant (RPG) funding, establishing two new core facilities and expanding the scope of a 3rd core facility. During Phase II we have sought to add depth to our basic science research programs with a long term goal of integrating basic research projects with translational research programs. During the coming year our specific aims include (a) continuation of our Administration Core, (b) support core facilities in Flow Cytometry, Bioinformatics, Imaging and Protein Purification and (c) support five junior faculty research projects and mentor these faculty members to independence. This CoBRE program will foster our long term goal of achieving NCI designation as a Clinical Cancer Center that serves the patient population of West Virginia and the surrounding Appalachian region.