MECHANISM OF NON-CLASSICAL RELEASE OF THE ANGIOGENESIS REGULATOR, IL1-ALPHA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是研究促血管生成多肽FGF1和IL1-α的跨膜转位机制，以及Notch信号对这些蛋白非经典释放的调节。该项目与项目2(L.Liww)在研究Notch在调节血管生成和癌变中的作用方面进行了互动。该项目可以帮助开发治疗心血管和肿瘤疾病的新方法，其基础是靶向致炎和促血管生成蛋白的非经典释放。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This goal of the project is to examine the mechanism of transmembrane translocation of pro-angiogenic polypeptides FGF1 and IL1-alpha and regulation of the non-classical release of these proteins by Notch signaling. This project is interactive with Project 2 (L. Liaw) in examining the role of Notch in the regulation of angiogenesis and carcinogenesis. The project can contribute to the development of new methods of treatment of cardiovascular and oncological disorders, based on targeting non-classical release of pro-inflammatory and pro-angiogenic proteins.